鞘脂代谢与妇科良恶性疾病的研究进展

doi:10.12280/gjfckx.20230400

摘要/Abstract

摘要：

妇科疾病是威胁女性健康的原因之一。妇科恶性肿瘤的发病率和死亡率均位居女性各系统疾病的前列，因肿瘤的复发及耐药导致疾病预后不佳。鞘脂（sphingolipid）是构成血浆脂蛋白的重要物质，对各种细胞功能及信号传导至关重要。鞘脂代谢参与调节炎症反应及癌细胞的增殖、迁移、侵袭和代谢等多种途径。研究证实，妇科良恶性疾病中存在神经酰胺、鞘磷脂、鞘氨醇-1-磷酸、鞘氨醇等鞘脂及其代谢物水平的差异。鞘脂水平的异常可影响疾病的进展和对放化疗的敏感性，分析鞘脂代谢或可预测疾病的转归。综述鞘脂代谢在妇科良恶性疾病中的研究进展，深入了解鞘脂的特性及功能，可以为探索和发现妇科良恶性疾病的发病机制、诊治及预后提供新的思路，以期改善患者的治疗前景和延长生存期。

关键词: 鞘脂类, 宫颈肿瘤, 子宫内膜肿瘤, 卵巢肿瘤, 子宫内膜异位症, 平滑肌瘤, 多囊卵巢综合征

Abstract:

Gynecological diseases are one of the causes that threaten women′s health. The incidence and mortality rate of gynecological malignant tumors are in the forefront among various systemic diseases in women, and the prognosis of the disease is poor due to tumor recurrence and drug resistance. Sphingolipids are important substances that make up plasma lipoproteins and are essential for various cellular functions and signaling. Sphingolipid metabolism is involved in regulating inflammatory responses and the proliferation, migration, invasion and metabolism of cancer cells. Studies have confirmed that there are differences in the levels of sphingolipids and their metabolites in benign and malignant gynecological diseases, including ceramides, sphingomyelin, sphingosine-1-phosphate and sphingosine. Abnormalities in sphingolipid levels can affect disease progression and sensitivity to chemoradiotherapy, analyzing sphingolipid metabolism may predict the outcome of disease. The review summarizes the research progress of sphingolipid metabolism in benign and malignant gynecological diseases to gain an in-depth understanding of the characteristics and functions of sphingolipids, which can provide new insights for exploring and discovering the pathogenesis, diagnosis, treatment and prognosis of benign and malignant gynecological diseases, in order to improve the treatment prospects and prolong the survival of patients.

Key words: Sphingolipids, Uterine cervical neoplasms, Endometrial neoplasms, Ovarian neoplasms, Endometriosis, Leiomyoma, Polycystic ovary syndrome

李振英, 孙晓彤, 邢广阳, 李晶晶, 柳婷婷, 张一凡. 鞘脂代谢与妇科良恶性疾病的研究进展[J]. 国际妇产科学杂志, 2023, 50(6): 649-654.

LI Zhen-ying, SUN Xiao-tong, XING Guang-yang, LI Jing-jing, LIU Ting-ting, ZHANG Yi-fan. Research Progress on Sphingolipid Metabolism and Benign and Malignant Gynecological Diseases[J]. Journal of International Obstetrics and Gynecology, 2023, 50(6): 649-654.

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