国际妇产科学杂志 ›› 2024, Vol. 51 ›› Issue (6): 676-679.doi: 10.12280/gjfckx.20240359

• 妇科肿瘤研究:病例报告 • 上一篇    下一篇

卵巢子宫内膜样癌合并Trousseau综合征一例

周婷, 梁宝权()   

  1. 215002 南京医科大学附属苏州医院妇科
  • 收稿日期:2024-04-19 出版日期:2024-12-15 发布日期:2024-12-16
  • 通讯作者: 梁宝权,E-mail:lbq5681494ln@163.com
  • 基金资助:
    2022年姑苏青年拔尖人才项目(2022209)

Ovarian Endometrioid Carcinoma Associated with Trousseau Syndrome: A Case Report

ZHOU Ting, LIANG Bao-quan()   

  1. Department of Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, Jiangsu Province, China
  • Received:2024-04-19 Published:2024-12-15 Online:2024-12-16
  • Contact: LIANG Bao-quan, E-mail: lbq5681494ln@163.com

摘要:

卵巢子宫内膜样癌(ovarian endometrioid carcinoma,OEC)早期无特殊临床表现,不易被发现。Trousseau综合征是与恶性肿瘤相关的血栓性疾病。报道1例以下肢静脉血栓为首发症状的OEC合并Trousseau综合征患者,抗凝治疗的同时进行围手术期准备,期间患者相继出现肺栓塞、脑梗死、心肌梗死等多脏器栓塞,经多学科综合评估后进行手术治疗,术后辅助化疗6个疗程,未见复发转移征象,且无新发梗死,预后良好。通过本例加强临床妇科医师对该病的了解,及时诊治,尽早使用抗血栓药物,同时积极切除原发病灶,术后第1天即可恢复抗凝治疗,严密监测凝血功能,及时调整抗凝药物剂量,可降低患者因栓塞导致的致残致死率,改善患者预后,保护女性健康。

关键词: 癌, 子宫内膜样, Trousseau 综合征, 血栓形成, 脑梗死, 心肌梗死

Abstract:

Ovarian endometrioid carcinoma (OEC) has no special clinical manifestations in the early stage and is not easy to be detect. Trousseau syndrome is a thrombotic disease associated with malignancy. It is reported that one patient with OEC combined with Trousseau syndrome diagnosed and treated in our hospital has lower extremity venous thrombosis as the first symptom, and perioperative preparations are carried out at the same time as anticoagulation therapy, during which the patient still has pulmonary embolism, cerebral infarction, myocardial infarction and other multi-organ embolism. After a multidisciplinary evaluation, we performed surgical treatment and six courses of postoperative adjuvant chemotherapy, and there were no signs of recurrence and metastasis, and there was no new infarction, resulting in a good prognosis. Through this case, the understanding of the disease by clinical gynecologists is strengthened, and the disease is diagnosed and treated in a timely manner. Early use of antithrombotic drugs, active resection of the primary lesion, resumption of anticoagulation on the first day after surgery, close monitoring of coagulation function and timely adjustment of anticoagulant dosage can reduce the rate of disability and mortality due to embolism, improve the prognosis of patients, and protect women′s health.

Key words: Carcinoma, endometrioid, Trousseau syndrome, Thrombosis, Brain infarction, Myocardial infarction