国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 504-507.

• 论著 • 上一篇    下一篇

黄芪治疗绝经后骨质疏松的抗氧化机制研究

崔红，贾文斌，杨奇，冯亚非   

  1. 266071 山东省青岛市，济南军区第一疗养院妇科（崔红），药剂科（贾文斌）；第四军医大学药学系（杨奇）；第四军医大学西京医院骨科（冯亚非）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15
  • 通讯作者: 冯亚非

The Anti-oxidative Effect of Astragalus Membranaceus on Postmenopausal Osteoporosis

CUI Hong，JIA Wen-bin，YANG Qi，FENG Ya-fei   

  1. Department of Gynecology（CUI Hong），Department of Pharmacy（JIA Wen-bin），The First Sanatorium of Jinan Military Area Command，Qingdao 266071，Shandong Province，China；School of Pharmacy，The Fourth Military Medical University，Xi′an 710032，China（YANG Qi）；Department of Orthopaedic Surgery，Xijing Hospital，The Fourth Military Medical University，Xi′an 710032，China（FENG Ya-fei）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15
  • Contact: FENG Ya-fei

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摘要： 目的：研究黄芪改善绝经后骨质疏松的具体机制。方法：选用32只3月龄SD雌性大鼠，随机分为假手术组、单纯去势组、黄芪治疗组和抗氧化剂组。后3组卵巢切除术后4周分别给予相应制剂灌胃，12周处死动物取材，检测血清和骨组织氧化应激水平[丙二醛（MDA）和超氧化物歧化酶（SOD）]、股骨骨密度和骨代谢指标[碱性磷酸酶（ALP）、血钙（Ca）、血磷（P）和骨钙素（OC）]。结果：单纯去势组的血清和骨组织中氧化应激水平比假手术组升高（P＜0.01），而股骨骨密度降低（P＜0.01）。与单纯去势组比较，黄芪治疗组和抗氧化剂组血清和骨组织中氧化应激水平降低（P＜0.01），同时股骨骨密度升高（P＜0.05），ALP和OC降低（P＜0.05）。结论：黄芪水提液能够通过抗氧化效应有效改善去卵巢大鼠的骨量丢失和骨代谢。

关键词: 黄芪, 骨质疏松, 骨密度, 动物实验

Abstract: Objective：To study the specific mechanisms underlying the improvement of astragalus membranaceus（AM） on postmenopausal osteoporosis. Methods：A total of 40 three-month-old female SD rats were randomly divided into four groups: sham group, ovariectomized（ＯＶＸ） group, the AM group, and the antioxidant group. Four weeks after surgery, each group was respectively given their treatment by gavage. Animals were sacrificed at 12 weeks, and levels of oxidative stress in serum and bone tissue, femur bone density and bone metabolism were analyzed. Results：Significantly higher oxidative stress level and lower bone mineral density were observed in the OVX group than that in the sham group （all P＜0.01）. Compared with the OVX group, AM group and antioxidant group showed significantly reduced oxidative stress level （P＜0.01）, while the femur bone density was significantly increased （P＜0.05） and alkaline phosphatase and osteocalcin were significantly decreased （both P＜0.05）. Conclusions：AM extract can effectively improve bone loss and bone metabolism in ovariectomized rats, and this improvement was achieved by its antioxidant effect.

Key words: Astragalus membranaceus, Osteoporosis, Bone density, Animal experimentation