盆底功能障碍性疾病动物模型和生物力学测量方法

doi:10.12280/gjfckx.20220278

摘要/Abstract

摘要：

盆底功能障碍性疾病（pelvic floor dysfunctions,PFD）已经成为危害女性健康的公共卫生问题,其发病机制迄今尚未完全明确。由于人体试验受到医学伦理的约束,动物模型成为研究PFD的重要工具。目前PFD的动物模型根据物种的不同大致分为啮齿类动物、小型哺乳动物、大型哺乳动物以及非人类灵长类动物（nonhuman primates）。通过研究动物模型现况发现,4类动物中啮齿类动物模型使用最多,非人类灵长类动物模型最为理想。模拟分娩是最主要的造模方法,基因技术可构建特定性质的动物模型。生物力学测量为盆底损伤病理和治疗效果的评估提供客观数据,可以进一步优化动物模型,为探索PFD发病机制及治疗方法提供更多助力。

关键词: 骨盆底, 尿失禁,压力性, 盆腔器官脱垂, 模型,动物, 动物实验, 生物力学现象, 盆底功能障碍性疾病

Abstract:

Pelvic floor dysfunctions (PFD) have become a public health problem that is increasingly harmful to women′s health, and its pathogenesis has not yet been fully understood. Because human trials are constrained by medical ethics, animal models are particularly important as a powerful tool for exploring PFD. The current animal models of PFD are roughly divided into rodents, small mammals, large mammals and nonhuman primates according to different species. By researching the status quo, it is found that among the four types of animals, rodent models are the most used, and nonhuman primate models are the most ideal. Simulating childbirth is the primary modeling method and genetic technology can be used to construct animal models with specific properties. Biomechanical measurements provide objective data for the pathology of pelvic floor injury and the evaluation of treatment effects, which can further optimize animal models and will provide more help for exploring the pathogenesis and treatment methods of PFD.

Key words: Pelvic floor, Urinary incontinence, stress, Pelvic organ prolapse, Models, animal, Animal experimentation, Biomechanical phenomena, Pelvic floor dysfunctions

王照, 平毅. 盆底功能障碍性疾病动物模型和生物力学测量方法[J]. 国际妇产科学杂志, 2022, 49(5): 502-506.

WANG Zhao, PING Yi. Animal Models of Pelvic Floor Dysfunctions and Biomechanical Measurements[J]. Journal of International Obstetrics and Gynecology, 2022, 49(5): 502-506.

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