国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (4): 245-248.

• 综述 • 上一篇    下一篇

重组活化因子Ⅶ在难治性产后出血中的应用

廖秋萍，颜建英   

  1. 350004 福州，福建医科大学研究生学院(廖秋萍)；福建医科大学教学医院福建省妇幼保健院妇产科(颜建英)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-08-15 发布日期:2010-08-15
  • 通讯作者: 颜建英

The Use of Recombinant Activated Factor Ⅶ in Intractable Postpartum Haemorrhage

LIAO Qiu-ping，YAN Jian-ying   

  1. Postgraduate Institue of Fujian Medical University，Fuzhou 350004， China（LIAO Qiu-ping）; Department of Gynecology and Obstetrics，Fujian Medical University Teaching Hospital Fujian Maternity and Child Health Hospital，Fuzhou 350001， China（YAN Jian-ying）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-08-15 Online:2010-08-15
  • Contact: YAN Jian-ying

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摘要： 产后出血是全球最常见孕产妇死亡原因之一。重组活化因子Ⅶ（rFⅦa）已成功应用于有凝血因子Ⅷ或Ⅸ抑制物的血友病患者，并用于其他凝血酶生成障碍性出血性疾病患者。近年也有研究表明，rFⅦa在治疗外伤、外科相关事件导致的严重出血，甚至在妇产科出血等非血友病的出血方面起到更广泛作用。现就rFⅦa在难治性产后出血中的临床应用进展进行综述。

关键词: 产后出血, 重组蛋白质类, 凝血酶, 治疗

Abstract: Postpartum haemorrhage is one of the most common causes of maternal death worldwide. Recombinant activated factor Ⅶ（rFⅦa） has already been successfully used for the treatment of bleeding episodes in patients with hemophilia A or B with formation of inhibitiors to factor Ⅷ or factor Ⅸ after replacement therapy and in other partients with inhibition of thrombin generating. Recently， scholars have found that rFⅦa plays wider roles in treating haemorrhage in patients with trauma， major surgery and even intractable obstetric and gynaecological hemorrhage. This article reviews the progress in the use of rFⅦa in intractable postpartum haemorrhage.

Key words: Postpartum hemorrhage, Recombinant proteins, Thrombin, Therapy