国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 21-23.

• 综述 • 上一篇    下一篇

NLRP 7基因在葡萄胎发生中的作用

周 薇 钱建华   

  1. 310006 杭州袁浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 钱建华

The Role of NLRP 7 Gene in Hydatidiform Mole

ZHOU Wei, QIAN Jian-hua   

  1. Women′s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15
  • Contact: QIAN Jian-hua

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摘要： 葡萄胎（HM）是异常人类妊娠，以绒毛滋养细胞增生、间质水肿，同时缺乏胚胎发育或者异常的胚胎发育为特征，是一种滋养细胞疾病（GTD）。超声的广泛使用使早期诊断和处理葡萄胎成为可能，但其确诊依据仍是组织学诊断；葡萄胎治疗有一定难度，且葡萄胎特别是复发性葡萄胎的预后不理想。葡萄胎的发生机制尚不明确，细胞遗传学研究发现葡萄胎组织染色体核型异常和基因印迹错误。最近对葡萄胎患者基因方面的研究发现，NLRP 7基因与复发性葡萄胎存在相关性。就葡萄胎及其与NLRP 7基因的研究进展综述。

关键词: 葡萄胎, 遗传学, 突变, 免疫, NLRP 7基因

Abstract: Hydatidiform mole （HM） is a gestational trophoblastic disease （GTD） characterized by proliferation of the pregnancy-associated trophoblastic tissue. With the widespread use of ultrasound, early diagnosis and treatment of hydatidiform mole is possible, but the diagnosis is still based on histopathology. The treatment of hydatidiform mole is difficult, and the prognosis of this disease is not vary good especially in recurrent hydatidiform mole. The mechanism of hydatidiform mole remains unclear. Different type of mole and the wrong chromosome gene imprinting have been found in genetics. Recently, the nucleotide-binding domain, leucine rich containing, pyrin domain containing 7 （NLRP 7） gene is found to connected with recurrent hydatidiform mole. This article will have a review of NLRP 7 gene in the role of hydatidiform mole.

Key words: Hydatidiform mole, Genetics, Mutation, Immunity, NLRP 7 gene