国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (1): 17-20.

• 综述 • 上一篇    下一篇

基因多态性与妊娠期高血压疾病

韩 云 徐友娣   

  1. 210006 南京医科大学附属南京第一医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-02-15 发布日期:2011-02-15
  • 通讯作者: 徐友娣

The Role of Gene in the Pathogenesis of Pregnancy Induced Hypertension

HAN Yun, XU You-di   

  1. Department of Obstertics and Gynecology, Nanjing First Hospital Affiliated Nanjing Medical University, Nanjing 210006, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-02-15 Online:2011-02-15
  • Contact: XU You-di

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摘要： 妊娠期高血压疾病是妊娠期特有的疾病，发病率高，对妊娠妇女、胎儿及新生儿危害极大，是导致孕产妇和围生儿死亡率增加的主要原因。近半个世纪，国内外学者对其发病机制进行了大量研究，有过度炎症反应、血管内皮损伤、氧化应激、母胎免疫平衡失调、滋养细胞缺血及遗传基因易感性等学说，但至今病因尚未阐明。众多研究发现，妊娠期高血压疾病具有较高遗传倾向，与某些基因多态性有关，与多基因有关，且更易发生原发性高血压。相关基因的突变可导致基因表达异常，使基因产物出现数量及功能异常，而诱发妊娠期高血压疾病。

关键词: 高血压, 妊娠性, 基因, 多态性现象, 遗传, 病因

Abstract: Pregnancy induced hypertension（PIH） is a characteristic disease of pregnant women with high morbidity, which does great harm to the pregnant, the fetus, and the newborns. It is one of the main causes of increasing mortality of the pregnant women and the puerperal babies. In nearly half a century, domestic and foreign scholars have done a lot of studies about its pathogenesis, such as producing excessive inflammatory response, endothelial injury, oxidative stress, maternal-fetal immune imbalance, trophoblastic ischemia, genetic susceptibility and other theories, but its pathogenesis has not yet been clarified. Recently many studies have found it has a higher genetic predisposition, associated with some gene polymorphisms and it is easier to develop to primary hypertension. Related gene mutation can cause abnormal gene expression, result in abnormalities of the number and function of gene products, so that induce PIH.

Key words: Hypertension, pregnancy-induced, Genes, Polymorphism, genetic, Pathogenesis