国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (6): 636-638.

• 综述 • 上一篇    下一篇

雌激素受体α与骨质疏松的关系

尹惠芬，狄文   

  1. 200127 上海交通大学医学院附属仁济医院妇产科，上海市妇科肿瘤重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 狄文

The Role of Estrogen Receptor α in Osteoporosis：An Update

YIN Hui-fen，DI Wen   

  1. Shanghai Key Laboratory of Gynecologic Oncology，Department of Obstetrics and Gynecology，Renji Hospital，School of Medicine，Shanghai Jiao Tong University，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15
  • Contact: DI Wen

PDF (PC)

4651

摘要： 绝经后妇女因为体内雌激素活性的降低，发生骨质疏松及骨折的风险显著增加，但雌激素抑制骨质疏松的作用机制长期以来并不明了。近年来，随着基因敲除等分子生物学技术的飞速发展，通过分别敲除小鼠体内不同骨细胞中的雌激素受体α（estrogen receptor α，ERα），逐渐揭示了ERα在雌激素与骨质疏松关系中的重要作用，对研发预防及治疗骨质疏松药物等具有重要的临床意义。由不同骨细胞中ERα对骨代谢的作用入手，分别分析阐明骨细胞、破骨细胞、成骨细胞祖细胞、成熟成骨细胞与骨细胞中的ERα在骨质疏松发病机制中的作用，对于开发骨质疏松药物的新靶点具有十分重要的意义。

关键词: 雌激素受体α, 骨质疏松, 骨质疏松, 绝经后, 绝经后期, 小鼠, 基因敲除

Abstract: Reduced bioavailability of estrogen increases osteoporosis and fracture risk in postmenopausal women significantly，but the mechanisms by which estrogen regulates bone mass are incompletely understood. In recent years，mouse models with cell-specific deletion of the estrogen receptor α（ERα） have provided novel insights into the function and signaling of ERα which provide opportunity to develop new drugs for preventing and treating osteoporosis. Illuminating the role of ERα in different bone cells，including chondrocyte，osteoclast，osteoblast progenitor cells，osteoblast and osteocyte to figure out the mechanisms of ERα in the pathogenesis of osteoporosis is of great importance to find new targets for osteoporosis.

Key words: Estrogen receptor alpha, Osteoporosis, Osteoporosis, postmenopausal, Postmenopause, Mice