关键词: 血流动力学检测, 子痫前期, 甲状腺功能, 代谢指标

Abstract: Objective: To investigate the correlation between hypothyroidism and hemodynamic parameters in PE.. Methods: The research was on 141 pregnant women chosen in Maternal-Child Health Centers affiliated to Nanjing Medical University. These women were classified into three groups:normal pregnancy group (39 cases), preeclampsia group (79 cases), pregnancy-induced hypertension (23 cases). Each woman’s thyroid stimulating hormone (TSH), serum free thyroxine (FT4), total protein (TP), albumin (ALB), total cholesterol (Chol), triglyceride (TG) levels were tested and compared. Using noninvasive hemodynamic monitoring three groups of pregnant women and the hemodynamic index: heart rate (HR), mean arterial pressure (map), preeclampsia group, the systolic blood pressure (SBP) and diastolic blood pressure (DBP), cardiac index (CI), cardiac output (CO), stroke index (SI), stroke volume (SV), peripheral vascular resistance index (SVRI), peripheral vascular resistance (SVR) changes. Results: ①The TSH of the participants in PE group, compared with those of the other groups ,was significantly increased (P < 0.05); The FT4 of the participants in PE group, compared with those of the other groups ,was not not significantly different (P > 0.05); ② The TP and ALB of the participants in PE group, compared with those of the other groups ,was significantly decreased (P < 0.05); The CHOL of the participants in PE group, compared with those of the other groups ,was significantly increased (P < 0.05), The TG of the participants in PE group, compared with those of the other groups ,was not not significantly different (P > 0.05); ③ The HR of the participants in PE group, compared with those of the other groups ,was significantly decreased (P < 0.05); the SBP、MAP、SVR、DBP and SVRI of the participants in PE group, compared with those of the other groups ,were significantly increased (P < 0.05);. The ET%、CO and CI of the participants in PE group, compared with those of the other groups ,were significantly decreased (P < 0.05);. ④Relationship between TSH and metabolic index: TSH was positively correlated with CHOL (r=0.2597, P<0.05). TSH was negatively correlated with TP and ALB (r=-0.2225/-0.3672, P<0.05). FT4 was positively correlated with TP and ALB (r=0.1713/0.2338 ). ⑤Relationship between TSH, FT4 and hemodynamic parameters: TSH and MAP/SBP were positively correlated (r=0.1954/0.1982, P < 0.05), FT4 and ET%/HR were positively related (r=0.1662/0.1757, P < 0.05). Conclusion: Preeclampsia is often associated with hypothyroidism; So it is necessary to check the level of thyroid hormone; the elevation of TSH was closely related to the occurrence of preeclampsia.

Key words: hemodynamics detection, preeclampsia, hypothyroidism, metabolic index