药物防治子痫前期的研究进展

doi:10.12280/gjfckx.20220660

摘要/Abstract

摘要：

子痫前期（pre-eclampsia，PE）作为妊娠期高血压疾病严重影响母婴健康和远期生存质量，然而对PE的临床干预局限于症状出现后的被动处理，往往造成母婴预后不良，因此对PE的症状前预防研究成为热点。阿司匹林是当前应用最广泛的PE预防性药物，然而随着对PE病因研究的不断深入，诸多药物被证明可用于预防PE。近年来，除阿司匹林以外的抗凝药、抗氧化剂、普伐他汀、二甲双胍及口服微生物组等多种药物在PE的防治研究中取得较大进展。本文综述可用于PE防治的主要药物，以期对临床实践中PE的早期预防有所帮助。

关键词: 子痫前期, 预防和防护用药, 阿司匹林, 肝素, 低分子量, 抗氧化剂, 普伐他丁, 二甲双胍, 口服微生物组

Abstract:

Pre-eclampsia (PE), as a hypertensive disorder of pregnancy, seriously affects maternal and infant health and long-term quality of life. However, clinical intervention for PE is limited to passive management after the oneset of symptoms, which often leads to poor prognosis of mother and infant. Therefore, the research on pre-symptomatic prevention of PE has become a hot topic. Aspirin is currently the most widely used preventive drug for PE. However, with the deepening of the research on the etiology of PE, many drugs have been proved to be used to prevent PE. In recent years, in addition to aspirin, anticoagulants, antioxidants, pravastatin, metformin, oral microbiome and other drugs have made great progress in the prevention and treatment of PE. This article reviews the main drugs that can be used for the prevention and treatment of PE, in order to help the early prevention of PE in clinical practice.

Key words: Pre-eclampsia, Protective agents, Aspirin, Heparin, low-molecular-weight, Antioxidants, Pravastatin, Metformin, Oral microbiome

王悦, 辛卫娟. 药物防治子痫前期的研究进展[J]. 国际妇产科学杂志, 2023, 50(1): 59-64.

WANG Yue, XIN Wei-juan. Progress on Pharmacological Prevention and Treatment of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 59-64.

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