国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (6): 663-666.

• 论著 • 上一篇    下一篇

DNMT1基因多态性和被动吸烟与宫颈癌的相关性

王玲，金平，宋易，孙元鹏   

  1. 730000 兰州大学第一医院（王玲）；南方医科大学附属深圳市妇幼保健妇产科（金平）；兰州大学第一临床医学院（宋易），基础医学院（孙元鹏）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 金平

Correlation of DNA Methyctransferase 1 Gene Polymorphisms and Passive Smoking with Cervical Cancer

WANG Ling，JIN Ping，SONG Yi，SUN Yuan-peng   

  1. The First Hospital of Lanzhou University, Lanzhou 730000, China（WANG Ling）；Department of Obstetrics and Gynecology, Shenzhen Maternity and Child Healthcare Hospital of Southern Medical University, Shenzhen 518000, China（JIN Ping）；The First Clinical Medical College（SONG Yi）, School of Basic Medical Sciences（SUN Yuan-peng）, Lanzhou University, Lanzhou 730000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-12-15 Online:2014-12-15
  • Contact: JIN Ping

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摘要： 目的：研究甘肃地区汉族女性DNA甲基转移酶1（DNMT1）基因多态性和被动吸烟与宫颈癌的相关性。方法：采用病例对照研究方法，选取甘肃地区100例宫颈癌患者和100例健康对照者，应用聚合酶链反应和基因测序法检测DNMT1基因多态性，比较不同基因型、被动吸烟与宫颈癌之间的关系。结果：被动吸烟者发生宫颈癌的相对危险性是无被动吸烟者的2.705倍（P＜0.05）；宫颈癌组rs16999593位点C等位基因频率高于对照组（P＜0.05）。结论：DNMT1基因的单核苷酸多态性和被动吸烟增加了宫颈癌的发病风险。

关键词: DNA（胞嘧啶-5-）-甲基转移酶, 等位基因, 序列分析, DNA, 烟草烟污染, 宫颈肿瘤

Abstract: Objective：To evaluate the possible relationship between DNA methyctransferase 1（DNMT1）gene polymorphisms and passive smoking with cervical cancer in Han population of Gansu province，China． Methods：A case-control study，DNMT1 gene polymorphism were detected by PCR and gene sequencing method in 100 patients of cervical cancer in Gansu province and 100 healthy controls. The relationship between different genotypes，passive smoking conditions and the risk of cervical cancer was analyzed． Results：Passive smoking has increased risk of developing cervical cancer by 2.705 times（P＜0.05）；the frequency of C allele of rs16999593 in cervical cancer patients was significantly higher than that in control group（P＜0.05）．Conclusions：These findings suggest that DNMT 1 gene polymorphism and passive smoking increased risk of cervical cancer.

Key words: DNA（Cytosine-5-）-methyltransferase, Alleles, Sequence analysis, DNA, Tobacco smoke pollution, Uterine cervical neoplasms