关键词: 卵巢肿瘤, 巨噬细胞, 肿瘤微环境, RNA, 吞噬作用, 治疗

Abstract: Tumor associated macrophages(TAMs) are the most common immune cells in the tumor microenvironment. They exist in tumor，distant pre-metastatic niche，as well as metastatic lymph node, and they are related to tumor progression and poor prognosis. There are many TAMs infiltrating into ovarian tumor and patients′ ascites, while the underlying mechanism is still unclear. Recently, role of lncRNA in the regulation of cell physiology has drawn more and more attention. LncRNA can affect the expression of coding gene by competing miRNA, directly interacting chromatin or protein, then regulate the function of cells. LncRNA has also been reported to regulate the differentiation of macrophages，for there are large number of lncRNAs differently expressing in M1 macrophages and M2 macrophages. Furthermore, lncRNA may play a role in the regulation of antigen presentation and phagocytosis of macrophages. Therapeutic methods targeting TAMs has been proved to be effective to reduce growth of ovarian cancer and production of ascites, and researches  trying to investigate the application of lncRNA inhibition in tumor therapy has also progressed to some extent in recent years.

Key words: Ovarian neoplasms, Macrophages, Tumor microenvironment, RNA, Phagocytosis, Therapy