关键词: 卵巢肿瘤, 治疗结果, Meta分析, 晚期上皮性卵巢癌, 理想肿瘤细胞减灭术, 评估模型

Abstract: Objective：To evaluate the accuracy of the evaluation models for advanced epithelial ovarian cancer (AEOC). Methods：Databases such as Pubmed, Cochrane Library, Medline, Embase and CNKI, VIP and CBM date were searched. Related literatures were published from the date of their establishment to March, 31, 2017. Reference articles of related articles were also researched. The searching language included Chinese and English. Meta-analysis was performed on studies meeting the inclusion criteria. Results：A total of 11 related studies were included. Meta-analysis showed that the total sensitivity and specificity of laparoscopy, CT and CA125 were 0.938, 0.816, 0.616 and 0.651, 0.830, 0.824 respectively. The total AUC of the corresponding model was calculated by calculating the area under the SROC curve. The AUC of the laparoscopy, CT and CA125 evaluation models were 0.949, 0.928 and 0.828, respectively. Conclusions：In all evaluation models, the CA125 evaluation model shows poor accuracy, while the CT evaluation model and the laparoscopic exploration evaluation model have higher accuracy, and the accuracy of laparoscopic exploration evaluation model is the highest. We expect more larger sample prospective clinical trials to validate the results of our study.

Key words: Ovarian neoplasms, Treatment outcome, Meta-analysis, Advanced epithelial ovarian cancer, Optimal debulking surgery, Evaluation model