关键词: 先兆子痫, 滋养层, 细胞死亡, 炎症, 焦亡

Abstract: Preeclampsia (PE) is the normal complication during pregnancy, Which seriously influences the maternal-fetal outcomes. The mechanisms are not clear. Vascular endothelial injury and over-reaction of inflammation are believed to be the main pathogenesis. It has been found that there is a close relationship between trophoblast pyroptosis and PE. On the one hand, pyroptosis reduces the invasion of trophoblast, which infiltrating too shallow or restricted, leading to abnormal blood vessels recasting, maternal-fetal interface ischemia and hypoxia. On the other hand, the release of inflammatory factors induces immune cells gathered, activates excessive inflammatory reactions, damages endothelial cell, leading to the occurrence of PE. In this paper, The relationships of trophoblast pyroptosis and the pathogenesis of PE are summarized as follows.

Key words: Preeclampｓｉａ, Ｔｒｏｐｈｏｂｌａｓｔ, Ｃｅｌｌ ｄｅａｔｈ, Ｉｎｆｌａｍｍａｔｉｏｎ, Ｐｙｒｏptosis