国际妇产科学杂志

国际妇产科学杂志 ›› 2018, Vol. 45 ›› Issue (3): 250-253.

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长链非编码RNA与子痫前期相关机制的研究进展

刘沙沙，左俊芳，崔洪艳   

  1. 300100  天津市中心妇产科医院
  • 收稿日期:2018-03-15 修回日期:2018-05-15 出版日期:2018-06-15 发布日期:2018-06-22

Advances in the Association between LncRNAs and Preeclampsia

LIU Sha-sha，ZUO Jun-fang，CUI Hong-yan   

  1. Tianjin Central Hospital of Gynecology Obstetrics，Tinajin 300100，China
  • Received:2018-03-15 Revised:2018-05-15 Published:2018-06-15 Online:2018-06-22

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摘要： 子痫前期（preeclampsia）是妊娠20周后出现的特发性高血压综合征，其病因和发病机制至今仍未完全阐明。长链非编码RNA（long non-coding RNA，lncRNA）是指长度大于200个核苷酸，不参与编码蛋白质的一类RNA。研究表明，lncRNA在基因表达水平、转录后修饰以及表观遗传修饰等细胞事件中发挥着重要作用。最新研究发现子痫前期胎盘中存在大量异常表达的lncRNA，推测lncRNA可能影响胎盘生长及生育过程，在子痫前期的发生中发挥了重要作用，深入研究子痫前期相关lncRNA及其调节机制可能有助于阐明子痫前期的发病机制，进而为子痫前期的预防和治疗提供新思路。

关键词: 先兆子痫, HELLP综合征, 长链非编码RNA, 滋养层细胞

Abstract: Preeclampsia (PE) is an idiopathic hypertension syndrome that occur after 20th week of gestation, whose etiology and pathogenesis have not yet been completely elucidated. Long non-coding RNA (lncRNA) is classified as RNA greater than 200 nucleotides in length that do not produce a protein product. LncRNAs are expressed with cellular and temporal specificity and have been shown to play a role in many cellular events, including the regulation of gene expression, post-transcriptional modifications and epigenetic modifications. In the current study, expressions of lncRNA were abnormal in PE placenta. It was speculated that lncRNA may affect the growth and reproduction of placenta and play an important role in the pathogenesis of PE, therefore further study of PE-related lncRNA and its regulatory mechanism may be helpful to elucidate the pathogenesis of PE and provide new ideas for PE prevention and treatment. Here, we review the current literature surrounding the lncRNAs related to PE.

Key words: Pre-eclampsia, HELLP syndrome, Long non-coding RNA, Trophoblast cell