辅助生殖妊娠并发子痫前期相关因素研究进展

摘要/Abstract

摘要： 子痫前期是严重影响母婴健康、造成母婴死亡的主要原因之一。辅助生殖技术（assisted reproductive technology，ART）是子痫前期的危险因素。随着不孕症患者逐年增多，通过辅助生殖治疗获得妊娠的比例不断增加，子痫前期发生率也随之增加。近年国内外研究发现子宫内膜异位症、多囊卵巢综合征、肥胖、多胚胎移植、冷冻胚胎移植、卵母细胞捐赠妊娠、着床期雌二醇峰值升高以及孕早期低浓度的人绒毛膜促性腺激素是子痫前期的危险因素，而孕激素是子痫前期的保护因素。这些因素单一或联合作用于子痫前期的发生发展。早期识别子痫前期危险因素、早期预防和早期干预是降低子痫前期发病率、改善母婴不良结局的关键。综述辅助生殖妊娠并发子痫前期的相关因素，为今后的辅助生殖妊娠围生期保健提供重要参考依据。

关键词: 先兆子痫, 生殖技术, 辅助, 体外受精, 胚胎移植, 不育, 女（雌）性, 危险因素

Abstract: Pre-eclampsia is one of the main reasons that seriously affect the health of mother and infant and cause their death. Assisted reproductive technology (ART) is a risk factor for pre-eclampsia. As infertility patients increases year by year ,the proportion of pregnancies obtained through ART is increasing, and the incidence of pre-eclampsia is also increasing. Recent studies at home and abroad have found that endometriosis, polycystic ovary syndrome, obesity, multiple embryo transfer, frozen embryo transfer, oocyte donation pregnancy, elevated estradiol peak during implantation, and low concentration human chorionic gonadotropin in early pregnancy are risk factors for pre-eclampsia, while progesterone is a protective factor for pre-eclampsia. These factors affect the development of pre-eclampsia alone or in combination. Early identification of risk factors for pre-eclampsia, early prevention and early intervention are the key to reduce pre-eclampsia morbidity and improve maternal and infant adverse outcomes. This article reviews the related factors of assisted reproductive pregnancy complicated with pre-eclampsia, and provides important reference for future perinatal health care of assisted reproductive pregnancy.

Key words: Pre-eclam, Fertilization in vitro, Embryo transfer, psia, Reproductive technology, assisted Infertility, female, Risk factors

中图分类号:

刘莹，王晨虹. 辅助生殖妊娠并发子痫前期相关因素研究进展[J]. 国际妇产科学杂志, 2019, 46(5): 485-489.

LIU Ying, WANG Chen-hong. Factors Related to Pre-Eclampsia after Pregnancy with Assisted Reproductive Technology[J]. Journal of International Obstetrics and Gynecology, 2019, 46(5): 485-489.

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