国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 351-354.

• 综述 • 上一篇    下一篇

雌激素受体基因多态性与子宫内膜异位症

倪 婕, 顾 林, 史颖莉   

  1. <SPAN lang=EN-US style=
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 顾 林

Estrogen Receptor Gene Polymorphisms and Endometriosis

NI Jie, GU Lin, SHI Ying-li   

  1. Nanjing Maternity and Child Health Hospital, Nanjing Medical and University, Nanjing 210004, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15
  • Contact: GU Lin

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摘要： 子宫内膜异位症（EMs）是一种雌激素依赖性疾病。雌激素与其受体（ER）结合后调节一系列基因的表达而发挥重要的生理作用。因此，ER的变化可能影响雌激素生物学效应。近年研究表明，ER基因多态性与EMs发病存在相关性。研究ER基因多态性与EMs的相关性对揭示EMs的发生、发展过程及治疗、判断预后等具有重要意义。就ER基因多态性与EMs发病相关性做文献综述。

关键词: 子宫内膜异位症, 受体, 雌激素, 雌激素受体α, 基因表达, 多态性, 限制性片段长度

Abstract: Endometriosis is an estrogen-dependent disease. Estrogen regulates the expression of several genes in combination with its receptor（ER）, thus playing an important physiological action. As a result, the change in ER may affect the biological effect of estrogen. Recent studies suggest that ER gene polymorphisms has an association with the risk of endometriosis, which is of significant to reveal the development, diagnosis, therapeutics and prognosis of endometriosis. This review summarizes current studies on correlation between ER gene polymorphisms and endometriosis.

Key words: Endometriosis, Receptors, estrogen, Estrogen receptor alpha, Gene expression, Polymorphism