食品补充剂在多囊卵巢综合征胰岛素抵抗型肥胖女性中的作用

doi:10.12280/gjfckx.20210729

摘要/Abstract

摘要：

多囊卵巢综合征（PCOS）是一种高发的生殖内分泌疾病。胰岛素抵抗和肥胖不仅是PCOS的主要临床特点,而且参与其发病过程。肌醇、二十二碳六烯酸、红曲、黄连素、姜黄素、益生菌制剂以及新兴功能性食品等食品补充剂可能通过多种调节机制和信号通路调节PCOS葡萄糖代谢,如增强胰岛素敏感性、调节肠道微生物群、提高抗炎和抗氧化活性、抑制肝脏糖异生以及增加葡萄糖转运等。PCOS肥胖患者使用特定食品补充剂可能改善胰岛素抵抗和代谢等症状和体征,同时促进排卵和提高妊娠率。鉴于此,从PCOS肥胖女性与胰岛素抵抗的关系为切入点,探讨食品补充剂的作用机制,为临床治疗PCOS提供潜在的治疗方法。

关键词: 多囊卵巢综合征, 胰岛素抗药性, 食品补充剂, 肥胖症, 代谢

Abstract:

Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with highly incidence. Insulin resistance and obesity not only are the main clinical characteristics of PCOS, but also participate in the pathogenesis of PCOS. Food supplements such as inositol, docosahexaenoic acid, red yeast rice, berberine, curcumin, probiotic preparations and emerging functional foods may regulate glucose metabolism in PCOS through a variety of regulatory mechanisms and signal pathways, such as enhancing insulin sensitivity, regulating intestinal microflora, increasing anti-inflammatory and antioxidant activity, inhibiting liver gluconeogenesis and increasing glucose transport. The use of specific food supplements in obese patients with PCOS may improve symptoms and signs including insulin resistance and metabolism, promote ovulation and increase the pregnancy rate. In view of this, the narrative review is to discuss the mechanism of food supplements from the point of view of the relationship between obese women with PCOS and insulin resistance, so as to provide potential treatment for clinical treatment of PCOS.

Key words: Polycystic ovary syndrome, Insulin resistance, Food supplements, Obesity, Metabolism

石百超, 王宇, 吴效科. 食品补充剂在多囊卵巢综合征胰岛素抵抗型肥胖女性中的作用[J]. 国际妇产科学杂志, 2022, 49(2): 166-171.

SHI Bai-chao, WANG Yu, WU Xiao-ke. The Role of Food Supplements in Insulin-Resistant Obesity Women with Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 166-171.

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