干细胞在宫腔粘连治疗中的应用

doi:10.12280/gjfckx.20220289

摘要/Abstract

摘要：

子宫内膜是子宫的重要组成部分,是胚胎着床的场所。子宫内膜可因感染、流产、过度刮宫等因素造成子宫内膜基底层损伤引发宫腔粘连,导致患者月经异常、复发性流产或不孕,严重影响女性的生活质量和生育。然而,目前对于宫腔粘连的各种治疗方法,疗效一般、复发率高。干细胞在再生医学中的广泛应用,使得干细胞疗法成为宫腔粘连的潜在治疗方法,即干细胞可用于子宫内膜的修复和再生。各项临床前实验已经证明,干细胞可减少动物模型受损子宫内膜纤维化,增加腺体数量,提高子宫内膜厚度。综述干细胞治疗宫腔粘连的理论基础、干细胞及其衍生物治疗宫腔粘连的研究进展。

关键词: 子宫疾病, 子宫内膜, 组织黏连, 干细胞移植, 间充质基质细胞, 再生医学

Abstract:

Endometrium is an essential component of the uterus and the site of embryo implantation. Several factors, including infection, abortion, excessive uterine curettage and so on, can lead to the damage of endometrial basal layer and intrauterine adhesion. It may result in several clinical manifestations such as amenorrhea, dysmenorrhea, sub-fertility/infertility and recurrent abortions to affect the physical and mental health and quality of life. However, various treatments for intrauterine adhesion has limited efficacy, which results in a high frequency of recurrence. The wide-ranging applications of stem cells in regenerative medicine is emerging as a potential therapy to treat intrauterine adhesion, which is to repaire and regenerate the endometrium. Number of pre-clincal reports has demonstrated stem cells treatment can decrease the fibrotic area, and increase the number of glands and the endometrial thickness and in animal models. This article reviews the theoretical basis of stem cell therapy for intrauterine adhsions and the research progress of stem cells and their derivatives in the treatment of intrauterine adhesions.

Key words: Uterine diseases, Endometrium, Tissue adhesions, Stem cell transplantation, Mesenchymal stromal cells, Regenerative medicine

张舒荣, 杨春润, 邵旭萍, 邹永辉, 李长忠. 干细胞在宫腔粘连治疗中的应用[J]. 国际妇产科学杂志, 2022, 49(4): 466-471.

ZHANG Shu-rong, YANG Chun-run, SHAO Xu-ping, ZOU Yong-hui, LI Chang-zhong. Application of Stem Cells in Intrauterine Adhesion Treatment[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 466-471.

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