国际妇产科学杂志 ›› 2022, Vol. 49 ›› Issue (5): 574-579.doi: 10.12280/gjfckx.20220269
收稿日期:
2022-04-14
出版日期:
2022-10-15
发布日期:
2022-10-24
通讯作者:
张月香
E-mail:zhangyx8986@163.com
基金资助:
FENG Qiang, ZHANG Yue-xiang△()
Received:
2022-04-14
Published:
2022-10-15
Online:
2022-10-24
Contact:
ZHANG Yue-xiang
E-mail:zhangyx8986@163.com
摘要:
产后出血(postpartum hemorrhage)是我国孕产妇死亡的首要原因,导致产后出血的主要因素有子宫收缩乏力、软产道裂伤、胎盘因素、贫血和凝血功能障碍等。近年来,由于我国生育政策的调整,孕产妇平均年龄逐渐升高,产后出血的发病率和严重程度也呈增长趋势,医疗机构应结合产妇实际情况识别产后出血,注重对产后出血原因的分析和研究,并及时进行预防和采取有效的应对措施,制定个体化治疗策略,保持母体血流动力学稳定,促进子宫收缩,实施适当的外科手术以及恰当的血液制品输注,必要时使用氨甲环酸、重组人活化因子Ⅶ和纤维蛋白原等药物,改善止血,使患者得到及时有效的治疗,降低出血相关死亡率,提高患者生活质量。
冯强, 张月香. 产后出血的治疗[J]. 国际妇产科学杂志, 2022, 49(5): 574-579.
FENG Qiang, ZHANG Yue-xiang. Treatment of Postpartum Hemorrhage[J]. Journal of International Obstetrics and Gynecology, 2022, 49(5): 574-579.
[1] |
中华医学会妇产科学分会产科学组. 产后出血预防与处理指南(2014)[J]. 中华妇产科杂志, 2014, 49(9):641-646. doi: 10.3760/cma.j.issn.0529-567x.2014.09.001.
doi: 10.3760/cma.j.issn.0529-567x.2014.09.001 |
[2] |
严小丽, 常青, 陈诚, 等. 产后出血患者的输血治疗原因及疗效研究[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(4):446-452. doi: 10.3877/cma.j.issn.1673-5250.2016.04.014.
doi: 10.3877/cma.j.issn.1673-5250.2016.04.014 |
[3] |
Neal S, Mahendra S, Bose K, et al. The causes of maternal mortality in adolescents in low and middle income countries: a systematic review of the literature[J]. BMC Pregnancy Childbirth, 2016, 16(1):352. doi: 10.1186/s12884-016-1120-8.
doi: 10.1186/s12884-016-1120-8 |
[4] |
白静, 李毅, 李娜, 等. 卡前列素氨丁三醇联合宫腔纱条填塞治疗宫缩乏力性产后出血效果观察[J]. 西部医学, 2018, 30(5):728-731. doi: 10.3969/j.issn.1672-3511.2018.05.025.
doi: 10.3969/j.issn.1672-3511.2018.05.025 |
[5] |
Escobar MF, Nassar AH, Theron G, et al. FIGO recommendations on the management of postpartum hemorrhage 2022[J]. Int J Gynaecol Obstet, 2022, 157(Suppl 1):3-50. doi: 10.1002/ijgo.14116.
doi: 10.1002/ijgo.14116 |
[6] |
鲁双艳, 吴斌, 王顺. 产科输血治疗原因及疗效评估[J]. 中国输血杂志, 2018, 31(6):631-633. doi: 10.13303/j.cjbt.issn.1004-549x.2018.06.015.
doi: 10.13303/j.cjbt.issn.1004-549x.2018.06.015 |
[7] |
Booker W, Moroz L. Abnormal placentation[J]. Semin Perinatol, 2019, 43(1):51-59. doi: 10.1053/j.semperi.2018.11.009.
doi: S0146-0005(18)30129-0 pmid: 30578147 |
[8] |
Dalvi SA. Difficult deliveries in cesarean section[J]. J Obstet Gynaecol Indi, 2018, 68(5): 344-348. doi: 10.1007/s13224-017-1052-x.
doi: 10.1007/s13224-017-1052-x |
[9] |
Moskowitz EE, Burlew CC, Moore EE, et al. Preperitoneal pelvic packing is effective for hemorrhage control in open pelvic fractures[J]. Am J Surg, 2018, 215(4):675-677. doi: 10.1016/j.amjsurg.2017.11.024.
doi: S0002-9610(17)30772-9 pmid: 29179908 |
[10] | 马宏伟, 刘兴会. 产后出血病因构成的变迁及应对措施[J]. 实用妇产科杂志, 2021, 37(3):165-168. |
[11] |
Widmer M, Piaggio G, Nguyen TMH, et al. Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth[J]. N Engl J Med, 2018, 379(8):743-752. doi: 10.1056/NEJMoa1805489.
doi: 10.1056/NEJMoa1805489 |
[12] |
Ai W, Zeng Y, Ma Y, et al. Side-effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta-analysis of randomized controlled trials[J]. Pharmacol Res Perspect, 2021, 9(2):e00745. doi: 10.1002/prp2.745.
doi: 10.1002/prp2.745 |
[13] |
官志芳. 卡前列素氨丁三醇治疗宫缩乏力性产后出血的临床效果及安全性分析[J]. 当代护士, 2020, 27(1):80-82. doi: 10.19791/j.cnki.1006-6411.2020.01.036.
doi: 10.19791/j.cnki.1006-6411.2020.01.036 |
[14] |
柯克, 董静. 卡前列素氨丁三醇联合缩宫素在减少凶险性前置胎盘产后出血中的临床效果及安全性[J]. 当代医学, 2022, 28(7):59-61. doi: 10.3969/j.issn.1009-4393.2022.07.020.
doi: 10.3969/j.issn.1009-4393.2022.07.020 |
[15] | World Health Organization. WHO recommendation on advance misoprostol distribution to pregnant women for prevention of postpartum haemorrhage[EB/OL]. Geneva: World Health Organization, 2020. https://www.ncbi.nlm.nih.gov/books/NBK564874/. |
[16] |
Ottun TA, Adewunmi AA, Rabiu AK, et al. Misoprostol and oxytocin versus oxytocin alone in the active management of the third stage of labour: a randomised, double-blind, placebo-controlled trial[J]. J Obstet Gynaecol, 2022, 42(5):1048-1053. doi: 10.1080/01443615.2021.1995342.
doi: 10.1080/01443615.2021.1995342 |
[17] |
Parry Smith WR, Papadopoulou A, Thomas E, et al. Uterotonic agents for first-line treatment of postpartum haemorrhage: a network meta-analysis[J]. Cochrane Database Syst Rev, 2020, 11(11):CD012754. doi: 10.1002/14651858.CD012754.pub2.
doi: 10.1002/14651858.CD012754.pub2 |
[18] |
Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis[J]. BMJ, 2012, 344:e3054. doi: 10.1136/bmj.e3054.
doi: 10.1136/bmj.e3054 |
[19] |
Li C, Gong Y, Dong L, et al. Is prophylactic tranexamic acid administration effective and safe for postpartum hemorrhage prevention?: A systematic review and meta-analysis[J]. Medicine(Baltimore), 2017, 96(1):5653. doi: 10.1097/MD.0000000000005653.
doi: 10.1097/MD.0000000000005653 |
[20] |
WOMEN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial[J]. Lancet, 2017, 389(10084):2105-2116. doi: 10.1016/S0140-6736(17)30638-4.
doi: S0140-6736(17)30638-4 pmid: 28456509 |
[21] | World Health Organization. WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage[EB/OL]. Geneva,Switzerland:World Health Organization, 2017. https://www.ncbi.nlm.nih.gov/books/NBK493081/. |
[22] |
Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40138 bleeding patients[J]. Lancet, 2018, 391(10116):125-132. doi: 10.1016/S0140-6736(17)32455-8.
doi: S0140-6736(17)32455-8 pmid: 29126600 |
[23] |
Sentilhes L, Sénat MV, Le Lous M, et al. Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery[J]. N Engl J Med, 2021, 384(17):1623-1634. doi: 10.1056/NEJMoa2028788.
doi: 10.1056/NEJMoa2028788 |
[24] |
Ansari JR, Kalariya N, Carvalho B, et al. Calcium chloride for the prevention of uterine atony during cesarean delivery: A pilot randomized controlled trial and pharmacokinetic study[J]. J Clin Anesth, 2022, 80:110796. doi: 10.1016/j.jclinane.2022.110796.
doi: 10.1016/j.jclinane.2022.110796 |
[25] |
Taeuber I, Weibel S, Herrmann E, et al. Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression[J]. JAMA Surg, 2021, 156(6):e210884. doi: 10.1001/jamasurg.2021.0884.
doi: 10.1001/jamasurg.2021.0884 |
[26] |
Epstein D, Solomon N, Korytny A, et al. Association between ionised calcium and severity of postpartum haemorrhage: a retrospective cohort study[J]. Br J Anaesth, 2021, 126(5):1022-1028. doi: 10.1016/j.bja.2020.11.020.
doi: 10.1016/j.bja.2020.11.020 pmid: 33341222 |
[27] |
Kayem G, Kurinczuk JJ, Alfrevic Z, et al. Uterine compression sutures for the management of severe postpartum hemorrhage[J]. Obstet Gynecol, 2011, 117(1):14-20. doi: 10.1097/AOG.0b013e318202c596.
doi: 10.1097/AOG.0b013e318202c596 pmid: 21213474 |
[28] |
Brogaard L, Hvidman L, Hinshaw K, et al. Development of the TeamOBS-PPH - targeting clinical performance in postpartum hemorrhage[J]. Acta Obstet Gynecol Scand, 2018, 97(6):677-687. doi: 10.1111/aogs.13336.
doi: 10.1111/aogs.13336 |
[29] |
Sentilhes L, Gromez A, Clavier E, et al. Fertility and pregnancy following pelvic arterial embolisation for postpartum haemorrhage[J]. BJOG, 2010, 117(1):84-93. doi: 10.1111/j.1471-0528.2009.02381.x.
doi: 10.1111/j.1471-0528.2009.02381.x |
[30] |
Yuan Q, Jin Y, Chen L, et al. Prophylactic uterine artery embolization during cesarean delivery for placenta previa complicated by placenta accreta[J]. Int J Gynaecol Obstet, 2020, 149(1):43-47. doi: 10.1002/ijgo.13072.
doi: 10.1002/ijgo.13072 pmid: 31778209 |
[31] |
Huque S, Roberts I, Fawole B, et al. Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial[J]. BMC Pregnancy Childbirth, 2018, 18(1):186. doi: 10.1186/s12884-018-1829-7.
doi: 10.1186/s12884-018-1829-7 |
[32] |
Fujioka I, Ichikawa Y, Nakajima Y, et al. Efficiency if leukocyte depletion filters and micro-aggregete filters following antra-operative cell salvage during cesarean section delivery[J]. Int J Obstet Anesth, 2020, 41:59-64. doi: 10.1016/j.ijoa.2019.07.003.
doi: S0959-289X(18)30462-X pmid: 31358431 |
[33] |
Khan KS, Moore P, Wilson M, et al. A randomised controlled trial and economic evaluation of intraoperative cell salvage during caesarean section in women at risk of haemorrhage: the SALVO (cell SALVage in Obstetrics) trial[J]. Health Technol Assess, 2018, 22(2):1-88. doi: 10.3310/hta22020.
doi: 10.3310/hta22020 pmid: 29318985 |
[34] |
Sun L, Xu Y, Huang L. Impact of Intraoperative Salvaged Blood Autotransfusion During Obstetric Hemorrhage on the Coagulation Function: A Retrospective Cohort Analysis[J]. Clin Appl Thromb Hemost, 2021, 27:10760296211064276. doi: 10.1177/10760296211064276.
doi: 10.1177/10760296211064276 |
[35] |
Stanworth SJ, Dowling K, Curry N, et al. A guideline for the haematological management of major haemorrhage: a British Society for Haematology Guideline[J]. Br J Haematol, 2022, 198(4):654-667. doi: 10.1111/bjh.18275.
doi: 10.1111/bjh.18275 |
[36] |
Lim G, Melnyk V, Facco FL, et al. Cost-effectiveness Analysis of Intraoperative Cell Salvage for Obstetric Hemorrhage[J]. Anesthesiology, 2018, 128(2):328-337. doi: 10.1097/ALN.0000000000001981.
doi: 10.1097/ALN.0000000000001981 pmid: 29194062 |
[37] |
Guo XY, Zhang Y, Zhao YY. Life-threatening postpartum hemorrhage (≥5 000 mL): a single center experience[J]. Ginekol Pol, 2022 Mar 22. doi: 10.5603/GP.a2021.0259.Epub ahead of print.
doi: 10.5603/GP.a2021.0259 |
[38] |
张辉, 张鹏, 张城, 等. 输血治疗在围生期产妇出血中的应用价值[J]. 中国妇幼保健, 2018, 33(3):526-528. doi: 10.7620/zgfybj.j.issn.1001-4411.2018.03.15.
doi: 10.7620/zgfybj.j.issn.1001-4411.2018.03.15 |
[39] |
Lavigne-Lissalde G, Aya AG, Mercier FJ, et al. Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial[J]. J Thromb Haemost, 2015, 13(4):520-529. doi: 10.1111/jth.12844.
doi: 10.1111/jth.12844 pmid: 25594352 |
[40] |
Khouadja H, Rouissi W, Mahjoub M, et al. Transfusion strategy for patients with severe postpartum hemorrhage: a retrospective study of 47 cases[J]. Pan Afr Med J, 2016, 25:169. doi: 10.11604/pamj.2016.25.169.7095.
doi: 10.11604/pamj.2016.25.169.7095 pmid: 28292131 |
[41] |
Colucci G, Helsing K, Biasiutti FD, et al. Standardized Management Protocol in Severe Postpartum Hemorrhage: A Single-Center Study[J]. Clin Appl Thromb Hemost, 2018, 24(6):884-893. doi: 10.1177/1076029618758956.
doi: 10.1177/1076029618758956 |
[42] |
Carvajal JA, Ramos I, Kusanovic JP, et al. Damage-control resuscitation in obstetrics[J]. J Matern Fetal Neonatal Med, 2022, 35(4):785-798. doi: 10.1080/14767058.2020.
doi: 10.1080/14767058.2020 |
[43] |
Albacar G, Sans T, Martín-Santos R, et al. An association between plasma ferritin concentrations measured 48 h after delivery and postpartum depression[J]. J Affect Disord, 2011, 131(1/2/3):136-142. doi: 10.1016/j.jad.2010.11.006.
doi: 10.1016/j.jad.2010.11.006 |
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