关键词: 巨细胞病毒, 巨细胞病毒感染, 妊娠初期, 产前诊断, 免疫球蛋白M, 免疫球蛋白G

Abstract:

Objective: To analyze the significance of the dynamic quantitative detection of cytomegalovirus (CMV) antibody levels in early pregnancy, and to provide a reference for clinicians to conduct the screening and diagnosis of CMV during pregnancy. Methods: A total of 810 pregnant women who were randomly selected from routine pregnancy examination in the Outpatient Department of Obstetrics and Gynecology of Huizhou Municipal Central Hospital from January to December 2021. All pregnant women were tested for IgG and IgM of CMV by electrochemiluminescence assay within 12 weeks of gestation, and were reviewed once every 1 to 2 weeks. Combine the two antibody quantification results to determine whether the pregnant woman was infected and the type of infection. Pathological analysis was performed on fetuses diagnosed with CMV infection in induced labor. Results: Among the 810 samples, 801 cases were infected with CMV, among which 783 cases (96.7%) were previously infected, 1 cases of CMV primary infection and 1 case of CMV recurrent infection. The primary infection rate and recurrent infection rate were both about 0.1%, 16 cases (2.0%) were IgM persistently positive, and 9 cases (1.1%) were not infected with CMV. One fetus of induced labor was diagnosed as disseminated congenital CMV infection. Conclusions: Dynamic and quantitative detection of CMV antibodies in early pregnancy can reflect the infection situation and infection type of pregnant women, effectively exclude the interference in clinical diagnosis and treatment, and avoid excessive medical intervention. Scientific and standardized CMV testing during pregnancy is the core of birth defect prevention and control.

Key words: Cytomegalovirus, Cytomegalovirus infections, Pregnancy trimester, first, Prenatal diagnosis, Immunoglobulin M, Immunoglobulin G