甲基化在子宫内膜癌中的研究进展

doi:10.12280/gjfckx.20220266

摘要/Abstract

摘要：

甲基化是表观遗传学的重要内容之一，甲基化异常与恶性肿瘤细胞增殖、自噬、凋亡、细胞间黏附、浸润和转移密切相关。子宫内膜癌是女性生殖系统常见的恶性肿瘤，研究发现，基因的异常甲基化与子宫内膜癌发病的高危因素、分型、肿瘤进展、早期诊断、化疗耐药、孕酮抵抗和预后评估有关。特异的甲基化标志物可用于子宫内膜癌的早期诊断和预后评估，调控关键基因的甲基化状态能改善子宫内膜癌细胞对化疗和孕酮的敏感性。综述DNA、RNA和组蛋白甲基化在子宫内膜癌发病机制、早期诊断、药物治疗和预后评估中的研究进展。

关键词: 子宫内膜肿瘤, 甲基化, 后成说, 遗传, 诊断, 治疗, 预后

Abstract:

Methylation is one of the important elements of epigenetics, and abnormal methylation is closely related to malignant tumor cell proliferation, autophagy, apoptosis, intercellular adhesion, infiltration and metastasis. Endometrial cancer is a common malignancy of the female reproductive system. Studies have shown that abnormal methylation of genes is associated with risk factors, types, tumor progression, early diagnosis, chemoresistance, progesterone resistance and prognostic assessment of endometrial carcinoma. Specific methylation markers can be used for early diagnosis and prognostic assessment of endometrial carcinoma. Regulating the methylation status of key genes can improve the sensitivity of endometrial carcinoma cells to chemotherapy and progesterone. This article provides an overview of research advances in DNA, RNA and histone methylation in the pathogenesis, early diagnosis, drug therapy and prognostic assessment of endometrial carcinoma.

Key words: Endometrial neoplasms, Methylation, Epigenesis, genetic, Diagnosis, Therapy, Prognosis

王湘炼, 徐炜, 朱姝, 王秀丽. 甲基化在子宫内膜癌中的研究进展[J]. 国际妇产科学杂志, 2023, 50(1): 6-10.

WANG Xiang-lian, XU Wei, ZHU Shu, WANG Xiu-li. Research Progress of Methylation in Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 6-10.

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