国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (6): 534-536.

• 综述 • 上一篇    下一篇

Toll样受体在妊娠期疾病的作用机制

邓力哲, 邵 勇   

  1. 401120 重庆市渝北区人民医院妇产科（邓力哲）；重庆医科大学附属第一医院妇产科（邵 勇）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-12-15 发布日期:2013-12-15
  • 通讯作者: 邵 勇

Toll-like Receptors on Mechanism of Disease in Pregnancy

DENG Li-zhe，SHAO Yong   

  1. Department of Obstetrics and Gynecology，Yubei District People′s Hospital，Chongqing 401120，China（DENG Li-zhe）；Department of Obstetrics and Gynecology，the First Affiliated Hospital of Chongqing Medical University，Chongqing 400016，China（SHAO Yong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-12-15 Online:2013-12-15
  • Contact: SHAO Yong

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摘要： Toll样受体（TLR）作为一种病原体识别受体备受关注，其在固有免疫中能识别病原体相关的分子模式（PAMP），通过刺激信号的级联反应导致细胞因子的产生和协同刺激因子的表达，从而在天然免疫和获得性免疫中发挥一系列作用。妊娠结局和先天性免疫密切相关，母胎界面特有的滋养细胞、羊膜细胞等也可以通过TLR参与先天性免疫反应，从而影响妊娠结局。综述TLR的结构、信号通路及其与妊娠期疾病的关系。

关键词: Toll样受体, 妊娠, 先兆子痫, 受体, 免疫

Abstract: Toll-like receptors（TLR） is a major concern pathogen recognition receptors nowadays. It plays a role in innate immunity via the identification of the pathogen associated molecular patterns. It connects innate immunity and acquired immunity by stimulating the signaling cascade of reactions lead to the production of cytokines and expression of costimulatory factors. Maternal-fetal trophoblast cells and amniotic membrane of cells specific to the interface，and so on，by TLR，also can identify the pathogen and involve in the innate immune response，which in turn have an impact on pregnancy outcome.

Key words: Toll-like receptors, Pregn, Pre-eclampsia, Receptors, immunologic