国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 224-227.

• 综述 • 上一篇    下一篇

左炔诺孕酮宫内节育系统防治子宫内膜异位症的作用机制

张 清,洛若愚, 熊霞鹂   

  1. 430060 武汉大学人民医院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 洛若愚

Mechanism of Levonorgestrel-releasing Intrauterine System in Treatment of Endometriosis

ZHANG Qing，LUO Ruo-yu，XIONG Xia-li   

  1. Department of Gynecology，Renmin Hospital of Wuhan University，Wuhan 430060，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: LUO Ruo-yu

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摘要： 左炔诺孕酮宫内缓释系统（LNG-IUS）作为一种有效的避孕工具，除用于人类节育外，在防治子宫内膜异位症（EMs）方面也取得了较好效果。国内外大量研究表明，EMs患者应用LNG-IUS治疗，可使子宫内膜萎缩，抑制内膜增殖和促使内膜变薄，从而减少逆流腹腔的经血量，达到预防异位内膜种植发生之目的。目前，与LNG-IUS治疗EMs相关的分子机制的报道很多，多数文献主要从细胞凋亡、血管形成相关因子以及性激素受体等方面来阐述。对LNG-IUS治疗EMs相关的分子机制的研究作一综述。

关键词: 子宫内膜异位症, 左炔诺孕酮, 迟效制剂, 子宫内膜

Abstract: LNG-IUS is an intrauterine contraceptive system also licensed for the treatment of endometriosis. Lots of researches，both at home and abroad ，have shown that LNG-IUS can make the endometrial atrophy，inhibit it's proliferation and prompt its thinning，then reduce the content of upstream into the peritoneal cavity ，and prevent the plant of ectopic endometrium，finaly.At present，there are many researches have reported the molecular mechanism associated with the treatment of LNG-IUS for endometriosis. Most of them focus on apoptosis，related factor of blood vessels formation， and sex hormone receptors.Now we will make a review for this molecular mechanism.

Key words: Endometriosis, Levonorgestrel, Delayed-action preparations, Endometrium