阴道上皮损伤修复与微生态环境的关系

doi:10.12280/gjfckx.20240880

摘要/Abstract

摘要：

阴道炎是妇产科的常见疾病，其发病率呈逐年上升的趋势。阴道微生态环境的研究促进了临床对阴道炎发病机制的了解，并优化了相应的治疗方案。然而，现阶段阴道炎的治疗仍面临疗效不尽人意、复发率高的困境。随着对阴道微生态环境的深入研究，发现阴道炎的发生发展与阴道上皮细胞密切相关，微生物及其代谢产物、炎症反应会直接或间接作用于阴道上皮细胞，进而影响阴道微生态环境。近年来，国内外学者提出维生素D及雌激素对阴道上皮细胞的修复有积极作用。从阴道微环境上皮细胞损伤与修复出发，探讨阴道炎的发病机制，可为提高阴道炎治愈率、降低复发率提供新思路。

关键词: 阴道炎, 炎症, 阴道病, 细菌性, 阴道, 细胞微环境

Abstract:

Vaginitis is a common disease in obstetrics and gynecology, and its incidence is increasing year by year. The research of vaginal microecological environment has promoted clinical understanding of the pathogenesis of vaginitis and optimized the corresponding treatment protocols. However, at this stage, the treatment of vaginitis still faces the dilemma of unsatisfactory efficacy and high recurrence rate. With the in-depth research of the vaginal microecological environment, it is found that the development of vaginitis is closely related to vaginal epithelial cells, and microorganisms, their metabolites, and inflammatory reactions will directly or indirectly act on vaginal epithelial cells, which in turn affect the vaginal microecological environment. In recent years, scholars at home and abroad have proposed that vitamin D and estrogen have a positive effect on the repair of vaginal epithelial cells. Discussing the pathogenesis of vaginitis from the damage and repair of epithelial cells in the vaginal microenvironment may provide new ideas to improve the cure rate and reduce the recurrence rate of vaginitis.

Key words: Vaginitis, Inflammation, Vaginosis, bacterial, Vagina, Cellular microenvironment

陈淑琳, 乔峤. 阴道上皮损伤修复与微生态环境的关系[J]. 国际妇产科学杂志, 2025, 52(1): 52-56.

CHEN Shu-lin, QIAO Qiao. Relationship between Vaginal Epithelial Injury Repair and Microecological Environment[J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 52-56.

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