锌与多囊卵巢综合征的关系

doi:10.12280/gjfckx.20240977

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是以卵巢多囊样改变、胰岛素抵抗、雄激素过高为主要特征的一种异质性内分泌疾病，严重影响女性的身心健康。然而目前PCOS的发病机制尚不明确，治疗方案有限。氧化应激是影响PCOS发病的一个重要因素，与胰岛素抵抗、高雄激素血症、慢性炎症密切相关。锌是人体内一种具有强大的抗氧化和抗炎特性的必需营养素，于代谢途径中参与胰岛素的合成、储存及胰岛素相关通路的调节。临床研究表明，PCOS患者相较于非PCOS人群表现出更低的血清锌水平，补充微量元素锌可改善PCOS患者的氧化应激、胰岛素抵抗和高雄激素状态。综述锌与PCOS代谢功能障碍和氧化应激的相关性，以期为PCOS预防管理和治疗提供参考。

关键词: 锌, 多囊卵巢综合征, 胰岛素抵抗, 氧化性应激, 雄激素增多症

Abstract:

Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder mainly characterized by polycystic ovarian changes, insulin resistance, and hyperandrogenism, which seriously affects women′s physical and mental health. However, its pathogenesis is still unclear and treatment options are limited. Oxidative stress is an important factor affecting the pathogenesis of PCOS and is closely related to insulin resistance, hyperandrogenemia, and chronic inflammation. Zinc is an essential nutrient with powerful antioxidant and anti-inflammatory properties. Metabolically, zinc is also involved in the synthesis and storage of insulin and regulating insulin-related pathways. Clinical studies have shown that patients with PCOS exhibit lower serum zinc levels compared to non-PCOS populations and that micronutrient zinc supplementation improves oxidative stress, insulin resistance, and hyperandrogenism in PCOS patients. The correlation between zinc and metabolic dysfunction and oxidative stress in PCOS is summarized, to provide a reference for the preventive management and treatment of PCOS.

Key words: Zinc, Polycystic ovary syndrome, Insulin resistance, Oxidative stress, Hyperandrogenism

徐淑颖, 徐海鹏, 王丽娜, 张阳. 锌与多囊卵巢综合征的关系[J]. 国际妇产科学杂志, 2025, 52(2): 217-221.

XU Shu-ying, XU Hai-peng, WANG Li-na, ZHANG Yang. Relationship between Zinc and Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2025, 52(2): 217-221.

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