国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 29-32.

• 综述 • 上一篇    下一篇

血管内皮生长因子基因与子宫内膜异位症

金志兴，朱芝玲，王莉   

  1. 200011 上海，复旦大学附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 朱芝玲

Vascular Endothelial Growth Factor Gene and Endometriosis

JIN Zhi-xing，ZHU Zhi-ling，WANG Li   

  1. Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: ZHU Zhi-ling

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摘要： 子宫内膜异位症（EMs）是一种病因未明，严重影响妇女生活的疾病。血管内皮生长因子（VEGF）可影响子宫内膜异位症的发生、发展，而VEGF基因中至少有30个单核苷酸具有多态性，目前学者们对-460 C/T、+405 G/C （也称为-634 G/C）、+936 C/T、-1154 G/A和-2578 A/C等的研究较多，这些位点可能通过影响VEGF的表达从而影响EMs。VEGF基因调控主要在转录及转录后水平，受药物、体内环境、体外环境等诸多因素的影响，其具体调控机制目前大多尚未明了。研究VEGF基因多态性及其调控途径以及对EMs的影响，将有助于学者们对EMs的发病机制作进一步了解，为探索治疗EMs的新方法提供思路。

关键词: 子宫内膜异位症, 血管内皮生长因子类, 基因表达, 基因

Abstract: Endometriosis seriously impacts on women′s life，whose etiology is still unknown. Vascular endothelial growth factor（ＶＥＧＦ） may affect the occurrence and development of endometriosis. VEGF gene has at least 30 single nucleotide polymorphisms，of which -460 C/T，+405 G/C （also known as -634 G/C），+936 C/T，-1154 G / A and -2578 A/C are more studied. These sites may impact on the development of endometriosis by influencing production of VEGF. The main gene regulation level of VEGF is in transcription and post-transcription，whose specific regulatory mechanism is not clear , and it can be affected by many factors，such as drugs，in vivo environment and in vitro environment. Research on the influence of VEGF gene polymorphisms and its regulation pathways on endometriosis will help scholars understanding the pathogenesis of endometriosis more so as to provide ideas of new ways to treat endometriosis.

Key words: Endometriosis, Vascular endothelial growth factors, Gene expression, Genes