国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 75-78.

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长链非编码RNA及其在妇科肿瘤发生发展中的作用

邱君君，华克勤   

  1. 200011 上海，复旦大学附属妇产科医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 华克勤

Long Non-Coding RNAs and Their Roles in the Development of Gynecological Tumors

QIU Jun-jun，HUA Ke-qin   

  1. Department of Obstetrics and Gynecology，Obstetrics and Gynecology Hospital of Fudan University，Shanghai 200011，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: HUA Ke-qin

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摘要： 长链非编码RNA（long non-coding RNA，lncRNA）曾被认为是基因组转录过程中的“噪音”而被科学界忽视。然而，近年来的许多研究表明lncRNA并非是“垃圾”，而是具有功能的RNA分子，故而受到广泛重视。相比于短链非编码RNA，lncRNA可谓是“后起之秀”，相关研究刚崭露头角，但就目前已有的研究表明，lncRNA在基因表达调控方面发挥着十分重要的作用，在临床疾病尤其是肿瘤的诊治方面有着不可估量的科学价值。综述lncRNA的功能、作用机制及其在妇科相关肿瘤发生发展中的意义。

关键词: RNA, 生殖器肿瘤, 女（雌）性, 长链非编码RNA

Abstract: Long non-coding RNA （lncRNA）, once regarded as "noise" in genomic transcription process, were ignored by the scientific community. However, more attentions are paid to lncRNA nowadays because recent studies have shown that they are not "junk" but functional RNAs. Although researches regarding to lncRNA are less because they are just "rising stars" in comparison to short non-coding RNA, these literatures have shown that lncRNA play important roles in the regulation of gene expression and provide immeasurable scientific value for future diagnosis and treatment of clinical disease especially for cancer. In this review, we summarized researches in the current status of the functions, mechanisms of lncRNA and their roles in the development of gynecological tumors.

Key words: RNA, Genital neoplasms, female, Long non-coding RNA