国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 87-90.

• 综述 • 上一篇    下一篇

宫颈癌免疫逃逸的相关机制

张慧杰，张淑兰   

  1. 110004 沈阳，中国医科大学盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 张淑兰

Mechanisms of Cervical Cancer-Immune Escape

ZHANG Hui-jie，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: ZHANG Shu-lan

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摘要： 宫颈癌是最常见的妇科恶性肿瘤。宫颈癌在形成、发展及外侵和转移过程中可以通过多种途径使机体细胞免疫和体液免疫功能下降、肿瘤细胞所处的免疫微环境发生变化而逃避机体免疫系统的监视。其中T淋巴细胞、树突细胞、自然杀伤细胞以及与巨噬细胞等有着双向作用的免疫细胞，在宫颈癌的免疫逃逸中起着非常关键的作用。综述宫颈癌免疫逃逸与免疫细胞之间的关系，深刻认识宫颈癌免疫逃逸机制，指导宫颈癌治疗理论研究，有助于宫颈癌防治研究的深入。

关键词: T淋巴细胞, 树突细胞, 杀伤细胞, 天然, 巨噬细胞, 宫颈肿瘤, 肿瘤逃逸

Abstract: Cervical cancer is the most common form of malignant gynecologic tumor. Cervical cancer in the process which are in the formation, development, invade, metastasis present can adopt different mechanisms to impair body′cellular and humoral immune function, and also change carcinoma cellular immunomicroenvironment , these changes can avoid body immune system′s attacks. Immune cells，such as T lymphocytes，dendritic cells，NK cells and macrophages play a dual role in the immune escape of cervical cancer. This article focuses on the relationship between the immune escape of cervical cancer and the immune cells reviewed. Understanding the immune evasion mechanisms used by cervical cancer will benefit the design of new therapeutic strategies for cervical cancer. A better understanding of the underlying mechanism will lead to more effective immunotherapy study．

Key words: T-lymphocytes, Dendritic cells, Killer cells, natural, Macrophages, Uterine cervical neoplasms