国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (1): 94-98.

• 综述 • 上一篇    下一篇

人脐带华通胶间充质干细胞的生物学特性及研究新进展

何蓓，杨晓清，张玉泉   

  1. 226001 江苏省南通大学附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: 张玉泉

Biological Characteristics and Their Latest Research Progress of Human Umbilical Cord Wharton′s Jelly-Derived Mesenchymal Stem Cells

HE Bei，YANG Xiao-qing，ZHANG Yu-quan   

  1. Department of Obstetrics and Gynecology，Affiliated Hospital of Nantong University，Nantong 226001，Jiangsu Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-02-15 Online:2016-02-15
  • Contact: ZHANG Yu-quan

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摘要： 人脐带华通胶间充质干细胞（human umbilical cord Wharton′s jelly-derived mesenchymal stem cell，hWJ-MSC）是一类具有自我更新、多向分化潜能的成体干细胞。由于其取自分娩过程中的废弃物——脐带，因此来源广泛、取材方便、不受任何伦理学限制，同时相对其他来源的成体干细胞例如骨髓间充质干细胞，hWJ-MSC免疫原性更弱、增殖能力更强、干细胞性能更加原始，使其成为一种新型的细胞来源，广泛应用于各种疾病模型的细胞移植以及基因治疗。综述新近研究的hWJ-MSC的生物学性状、增殖分化潜能、免疫性能以及其在各类疾病中的应用进展。

关键词: 干细胞, 间质干细胞, 脐带, 治疗, 人脐带华通胶间充质干细胞

Abstract: Human umbilical cord Wharton′s jelly-derived mesenchymal stem cell （hWJ-MSC） is a kind of adult stem cell which has self-renewal ability, multiline age differentiation potential. As isolated from discarded tissue (umbilical cord) after birth, they are considered wide resource, easy to be acquired and not restricted by ethics. Compared to other source of adult stem cells such as bone marrow mesenchymal stem cells, hWJ-MSC has lower immunogenicity, higher proliferation, more primitive stem cell performance, which make hWJ-MSC become a new cell resource. hWJ-MSC has great therapeutic potential in cell transplantation, gene therapy for various diseases. In this review, we will discuss the biological characteristics, proliferation and differentiation potential, and immunological characteristics of hWJ-MSC, and mainly focus on the latest progress of their application on various diseases.

Key words: Stem cells, Mesenchymal stem cells, Umbilical cord, Therapy, Human umbilical cord Wharton′s jelly-derived mesenchymal stem cells