国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 57-59.

• 综述 • 上一篇    下一篇

靶向脂质体在卵巢癌中的研究应用


叶红霞,孙江川, 常淑芳   

  1. 400010 重庆医科大学附属第二医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 常淑芳

Targeting Liposomes Towards Ovarian Anticancer Study

YE Hong-xia，SUN Jiang-chuan，CHANG Shu-fang   

  1. Department of Obstetrics and Gynecology，the Second Affiliated Hospital of Chongqing Medical University，Chongqing 400010，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: CHANG Shu-fang

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摘要： 化疗是目前治疗卵巢癌的重要手段，将化疗药物包被于脂质体，利用脂质体的靶向性将药物运输至靶部位释放，可提高治疗指数，降低毒副反应。各种特制的脂质体作为药物载体治疗卵巢癌的研究日益增多，就脂质体靶向治疗卵巢癌及改善机体耐药性进行探讨，着重讨论脂质体被动靶向性及主动靶向性的实用性和有效性。

关键词: 卵巢肿瘤, 化学疗法, 辅助, 脂质体, 抗药性, 肿瘤

Abstract: At present，chemotherapy is an important way to treat the ovarian Neoplasms. The chemotherapy drugs can be coated in the liposomes and delivered to target site to be released with the use of liposomes′targeting.In this way，therapeutic index has been improved and toxicity side effects has been reduced. All kinds of specially designed liposomes as drug carriers treating ovarian cancer increases day by day. Here，we provide an overview of liposomal targeting therapeutics and overcoming drug resistance to ovarian cancer cell，focusing on the practicality and effectiveness of passive targeting and active targeting of liposomes in the treatment of the ovarian cancer.

Key words: Ovarian neoplasms, Chemotherapy, adjuvant, Liposomes, Drug resistance, neoplasm