国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 52-56.

• 综述 • 上一篇    下一篇

上皮间充质转化在上皮性卵巢肿瘤侵袭和转移中的作用

郭 融,汪希鹏   

  1. 200001 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 汪希鹏

The Effect of Epithelial to Mesenchymal Transition in Epithelial Ovarian Carcinoma Invasion and Metastasis

GUO Rong，WANG Xi-peng   

  1. Department of Obstetrics and Gynecology，Renji Hospital Affiliated to Shanghai Jiao Tong University School，Shanghai 200001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: WANG Xi-peng

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摘要： 卵巢恶性肿瘤是常见的女性生殖系统三大恶性肿瘤之一，大多数起源于卵巢表面上皮。其中上皮性卵巢癌（epithelial ovarian carcinoma，EOC）是死亡率最高的妇科恶性肿瘤。上皮间充质转化（epithelial to mesenchymal transition，EMT）是胚胎发育过程中的基本现象。近年研究发现，EMT不仅参与胚胎形成、组织的再生和修复，而且与上皮细胞性肿瘤的恶性进展也存在重要的联系。EMT的形成机制和进展的相关研究对于上皮性肿瘤的防治有重要意义，因此关于EMT在上皮性肿瘤形成和侵袭过程中的机制研究受到越来越多的关注。综述上皮性卵巢癌中EMT形成机制及其与卵巢上皮性肿瘤微环境和上皮性卵巢肿瘤相关信号通路的关系。

关键词: 上皮间充质转化, 卵巢上皮性肿瘤, 卵巢表面上皮细胞, Wnt信号通路

Abstract: Ovarian malignant cancer is the third most common gynecologic cancer. Most ovarian cancers are classified as
“epithelial”and were believed to arise from the surfaceof the ovary. The epithelial to mesenchymal transition is generally considered to be a critical progress in embryogenesis and organ development. Recent researches demonstrated that epithelial to mesenchymal transition was essential to not only for embryogenesis but also for tissue regeneration and wound healing. However， epithelial to mesenchymal transition has a more sinister role in epithelial ovary tumor progression and metastasis.Considerable attention has centred around the mechanistic investigation of epithelial to mesenchymal transition in the epithelial ovary tumor progression and metastasis. In this review，we summarize microenvironment，mircroRNAs and major signaling pathways that participate in the epithelial-mesenchymal transitions during both development and tumor metastasis.

Key words: Epithelial to mesenchymal transition, Epithelial ovary tumor, Ovarian surface epithelial cell, Wnt signal pathway