DKK3、Wnt/β-连环蛋白信号通路与宫颈癌关系的研究进展

doi:10.12280/gjfckx.20201169

摘要/Abstract

摘要：

宫颈癌为女性恶性肿瘤之一,对于其发病机制及所涉及的通路分子的研究越来越深入。其中Wnt/β-连环蛋白（β-catenin）信号通路的研究受到高度关注。Wnt/β-catenin信号通路涉及广泛的生理和病理过程,包括细胞生长、分化、个体发育、迁移、遗传稳定性、凋亡、干细胞自我更新和维持成人组织稳态。稳定的β-catenin在细胞质中积累并转移到细胞核,激活Wnt/β-catenin信号通路,是多种癌症的诱发因素之一。β-catenin的积累在Wnt/β-catenin信号通路占据核心位置。β-catenin通过Wnt/β-catenin信号通路驱动靶基因,参与宫颈癌多步骤的发生及发展。而Dickkopf相关蛋白3（DKK3）可能通过降解β-catenin、阻断β-catenin的核转运,抑制Wnt/β-catenin信号通路,在抑制宫颈癌的发生、发展中发挥潜在作用。因此,深入研究DKK3、Wnt/β-catenin信号通路与宫颈癌的关系,显得尤为重要。

关键词: 宫颈肿瘤, Dickkopf相关蛋白3, β连环素, Wnt信号通路, 基因,肿瘤抑制

Abstract:

Cervical cancer is one of the malignant tumors in women, and the pathogenesis and related pathway molecules have been studied more and more deeply. Among them, the research on Wnt/β-catenin signaling pathway has attracted great attention. The Wnt/β-catenin signaling pathway involves a wide range of physiological and pathological processes, including cell growth, differentiation, ontogeny, migration, genetic stability, apoptosis, stem cell self-renewal, and maintenance of adult tissue homeostasis. Stable β-catenin is accumulated in the cytoplasm and transferred to the nucleus, which activates the Wnt/β-catenin signaling pathway and is one of the inducing factors of multiple cancers. The accumulation of β-catenin occupies a core position in the Wnt/β-catenin signaling pathway. β-catenin drives target genes through Wnt/β-catenin signaling pathway and participates in the multi-step occurrence and development of cervical cancer. DKK3 may inhibit the Wnt/β-catenin signaling pathway by degrading β-catenin, blocking the nuclear transport of β-catenin, and thus become a potential key role in the inhibition of cervical cancer. Therefore, it is particularly important to study the relationship between DKK3, Wnt/β-catenin signaling pathway and cervical cancer.

Key words: Uterine cervical neoplasms, Dickkopf-3, Beta catenin, Wnt signaling pathway, Genes,tumor suppressor

王玲, 王志莲. DKK3、Wnt/β-连环蛋白信号通路与宫颈癌关系的研究进展[J]. 国际妇产科学杂志, 2021, 48(5): 539-542.

WANG Ling, WANG Zhi-lian. Research Progress on the Relationship between DKK3, Wnt/β-Catenin Signaling Pathway and Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 539-542.

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