国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 585-588.

• 综述 • 上一篇    下一篇

多发性硬化与妊娠

张婉莹, 陈 玲, 周 颖, 凌 斌   

  1. 230001 合肥,安徽医科大学附属省立医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 凌 斌

Multiple Sclerosis and Pregnancy

ZHANG Wan-ying，CHEN Ling，ZHOU Ying，LING Bin   

  1. Department of Obstetrics and Gynecology，Anhui Provincial Hospital Affiliated to Anhui Medical University，Hefei 230001， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15
  • Contact: LING Bin

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摘要： 多发性硬化是中枢神经系统的脱髓鞘性自身免疫性疾病，女性为主要易感人群，多见于育龄期妇女。多发性硬化本身不会增加妊娠合并症，有些研究发现患有多发性硬化的妊娠妇女引产、使用产钳及娩出低出生体质量儿、身材矮小儿的发生率增加，但是研究显示多发性硬化并没有增加胎儿先天性畸形及死亡率。妊娠、硬膜外麻醉、哺乳不会增加多发性硬化的活动性、复发率及疾病进展情况。综述多发性硬化与妊娠的相互影响以及妊娠期的药物治疗等情况。

关键词: 多发性硬化, 妊娠, 复发, 治疗

Abstract: Multiple sclerosis is a autoimmune demyelinating disease that affects the central nervous system，more commonly seen in women than in men，especially childbearing-age women. Multiple sclerosis itself does not increase complication of pregnancy. Although some studies have found that pregnant women with multiple sclerosis have increased incidences of their induced labor，the use of obstetric forcep and delivered low birth weight children，short stature children，the studies show no increase in congenital malformations and fetal mortality. Pregnancy，epidural anesthesia and breast-feeding do not increase the incidence，relapse rate and disease progression of multiple sclerosis. In this paper，the relationship between pregnancy and multiple sclerosis were reviewed，including interaction of multiple sclerosis and pregnancy and drug treatment during pregnancy and so on.

Key words: Multiple sclerosis, Pregnancy, Recurrence, Therapy