国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (3): 234-236.

• 综述 • 上一篇    下一篇

子宫内膜异位症抗血管生成研究进展

季 慧, 冒韵东   

  1. 210029 南京医科大学第一附属医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-06-15 发布日期:2013-06-15
  • 通讯作者: 冒韵东

Anti-angiogenic Research Progress of Endometriosis

JI Hui，MAO Yun-dong   

  1. State Key Laboratory of Reproductive Medicine，First Affiliated Hospital，Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-06-15 Online:2013-06-15
  • Contact: MAO Yun-dong

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摘要： 血管生成在子宫内膜异位症（EMs）的发病过程中起重要作用。过去10年中，越来越多的研究将重点集中在抗血管生成方面，现已证实许多化学物质对子宫内膜异位病灶有抗血管生成的作用，包括生长因子抑制剂、内源性血管生成抑制剂、他汀类药物、环氧化酶-2（COX-2）抑制剂、免疫调节剂、多巴胺受体激动剂和过氧化物酶体增殖激活受体（PPAR）激动剂等。现将EMs抗血管生成的研究进展加以概括总结，并探讨抗血管生成物质治疗EMs的潜在作用。

关键词: 子宫内膜异位症, 血管内皮生长因子A, 血管生成抑制剂, 环氧化酶2抑制剂, 多巴胺激动剂, 过氧化物酶体增殖物激活受体

Abstract: Angiogenesis plays an important role in the pathogenesis of endometriosis. Based on this observation，many substances capable of inhibiting blood vessel formation have been tested to treat the disease during the last decade. These include growth factor inhibitors，endogenous angiogenesis inhibitors，statins，cyclo-oxygenase-2 inhibitors，immunomodulators，dopamine agonists and peroxisome proliferator-activated receptor agonists. This review will summarize recent anti-angiogenic researches of endometriosis and discuss the potential role of anti-angiogenic substances in the treatment of endometriosis.

Key words: Endometriosis, Vascular endothelial growth factor A, Angiogenesis inhibitors, Cyclooxygenase 2 inhibitors, Dopamine agonists, Peroxisome proliferator-activated receptors