国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (5): 387-390.

• 综述 • 上一篇    下一篇

Toll样受体及其基因多态性与早产

段丽君;曾蔚越   

  1. 610041 成都，四川大学华西第二医院妇产科
  • 收稿日期:2008-12-26 修回日期:1900-01-01 出版日期:2009-10-15 发布日期:2009-10-15
  • 通讯作者: 曾蔚越

Toll Like Receptor and Gene Polymorphisms and Preterm Birth

DUAN Li-jun;ZENG Wei-yue   

  1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Received:2008-12-26 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15
  • Contact: ZENG Wei-yue

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摘要： Toll样受体（TLRs）是近年发现的固有性免疫系统中的细胞跨膜受体及病原模式识别受体之一，在对病原微生物的识别与免疫
应答中起着重要的作用。基因多态性影响机体对疾病的遗传易感性，TLRs的基因多态性与炎性应答损伤和感染性疾病的遗传易感性相关。随着生
殖免疫学研究的进步，TLRs及其基因多态性在早产中的相关研究已逐步展开，对其深入认识和研究将为早产诊断、治疗及预后判断提供新思路和
手段。

关键词: Toll样受体, 基因多态性, 早产, 免疫, 胎盘

Abstract: Toll like receptors （TLRs） have been identified as transmembrane signal transduction proteins in
recent years. As a group of pattern recognition receptors （PRRs）, TLRs are important regulators of the innate immune
response based on their ability to recognize and respond to pathogen-associated molecular patterns expressed by
microbes. Genetic polymorphisms affect the susceptibility of individuals and single nucleotide polymorphisms of TLR
genes, which are associated with the inflammatory responses and susceptibility to infectious diseases. With the development of
reproductive immunology, relevant studies of TLRs and their gene polymorphism and preterm birth have been gradually carried
out, providing new concepts and ideas for diagnosis, treatment and prognosis of premature cases.

Key words: Toll like receptors, Genetic polymorphisms, Preterm birth, Immune, Placenta