国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 120-123.

• 综述 • 上一篇    下一篇

上皮性卵巢癌起源学说的研究进展


徐兵，周颖，胡卫平   

  1. 230001 合肥，安徽医科大学附属省立医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 胡卫平

Advances in the Origin of Ovarian Epithelial Cancer

XU Bing，ZHOU Ying，HU Wei-ping   

  1. Department of Obstetrics and Gynecology，Anhui Provincial Hospital Affiliated to Anhui Medical University，Hefei 230001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15
  • Contact: HU Wei-ping

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摘要： 上皮性卵巢癌是一组异质性肿瘤，其组织来源尚未明确。目前上皮性卵巢癌的起源学说主要包括卵巢表面生发上皮学说、第二苗勒系统学说、卵巢外组织起源学说及干细胞学说。近些年，形态学和分子标记物如p53蛋白、bcl-2蛋白、配对盒蛋白（PAX8）、钙网膜蛋白（calretinin）和微管蛋白（tubulin）显示输卵管上皮与高、低级别浆液性卵巢癌的组织起源密切相关，而动物实验发现卵巢门细胞具有干细胞特性，表达干细胞标记乙醛脱氢酶1（ALDH1）和富含亮氨酸重复单位的G蛋白耦联受体5（Lgr5）具有增殖分化、自我更新的能力，因此输卵管学说和干细胞学说成为卵巢癌起源学说的研究热点。

关键词: 卵巢肿瘤, 上皮细胞, 苗勒管, 干细胞

Abstract: Ovarian epithelial cancer belongs to a heterogeneous group of tumors，of which tissue type of origin is uncertain. The current researches on the origin of ovarian epithelial malignancy mainly contain three theories including ovarian surface epithelium doctrine，the secondary müllerian system doctrine，extraovarian tissue of origin doctrine and stem cell doctrine. In recent years，morphologic analysis and immunohistochemistry of molecular markers such as p53，bcl-2，PAX8，calretinin，tubulin show that high-grade and low-grade serous ovarian cancers are closely correlated with fallopian tube，but experiment in mice shows ovarian hilum cells have the characteristic of stem cell and express ALDH1 and Lgr5，which are the stem cell markers. The ovarian hilum cells have the capacity of proliferation，differentiation and self-renewal. Therefore the origin of ovarian cancer is mainly focused on fallopian tube theory and stem cell theory.

Key words: Ovarian neoplasms, Epithelial cells, Mullerian ducts, Stem cells