国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 132-135.

• 综述 • 上一篇    下一篇

人乳头瘤病毒衣壳蛋白与宫颈病变

黄成琳，张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15
  • 通讯作者: 张淑兰

Human Papillomavirus′ Capsid Proteins and Cervical Lesions

HUANG Cheng-lin，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology，Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15
  • Contact: ZHANG Shu-lan

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摘要： 宫颈癌严重危害妇女健康，人乳头瘤病毒（ＨＰＶ）感染是其首要病因。临床医师一直致力于寻找一种能有效判断宫颈病变级别及预测预后的诊断方法。HPV衣壳蛋白包括主要衣壳蛋白（L1壳蛋白）和次要衣壳蛋白（L2壳蛋白），这两种蛋白在组装成病毒颗粒、协助病毒入胞及引起机体免疫反应等多个方面发挥重要作用。近年研究表明，L1壳蛋白可用于预测宫颈病变的进展与消退。以L1及L2壳蛋白为基础研发的HPV预防性疫苗在临床试验中得到了很好的预防效果。综述HPV生物学特点及近年来有关HPV衣壳蛋白在宫颈病变的研究进展。

关键词: 乳头状瘤病毒科, 子宫颈, 宫颈上皮内瘤样病变, 活组织检查, L1壳蛋白, L2壳蛋白, 免疫组织化学

Abstract: Cervical cancer seriously endangers women′s health，and human papillomavirus（HPV） is considered to be the primary cause. Doctors have been striving to find an effective diagnostic method for judging cervical lesions level and predicting its prognosis. HPV capsid proteins comprise the major capsid protein（L1 capsid protein） and the minor capsid protein （L2 capsid protein），and these two proteins play an important role in assembling into virus particles，trafficking HPV to the cell，and causing the host′s immune reactions. In recent years，studies have shown that the L1 capsid protein can be used to predict the progress and subsidence of cervical lesions. HPV prophylactic vaccines，which are exploited on the basis of the L1 and L2 capsid protein，are proved to get a good preventive effect in clinical trials. This paper reviews the biological characteristics of HPV and researches progress on HPV capsid protein in cervical lesions in recent years.

Key words: Papillomaviridae, Cervix uteri, Cervical intraepithelial neoplasia, Biopsy, L1 capsid protein, L2 capsid protein