国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (4): 331-334.

• 综述 • 上一篇    下一篇

人附睾蛋白4鉴别诊断妇科肿瘤新进展


张双革,张 虹   

  1. 300100 天津市中心妇产科医院检验科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-08-15 发布日期:2013-08-15

Progress of Human Epididymis Protein 4 in Differential Diagnosis of Gynecologic Oncology

ZHANG Shuang-ge，ZHANG Hong   

  1. Department of Laboratory Medicine，Tianjin Central Hospital of Obstetrics and Gynecology，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-08-15 Online:2013-08-15

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5130

被引次数

12

摘要： 人附睾蛋白4（HE4）最早是在人附睾上皮细胞中发现的，定位于染色体20q12～13.1上，全长约12 kb。在鉴别绝经前妇女附件包块良恶性时，HE4比CA125有更好的特异度；单用HE4或与CA125联合检测，不但有助于鉴别卵巢肿瘤的良恶性，发现早期卵巢癌，而且HE4也是监测卵巢癌术后治疗效果、预测是否复发的重要指标。HE4在子宫内膜癌各期表达均升高，且在子宫内膜癌早期，HE4检测敏感度比CA125高；HE4与子宫内膜癌侵入肌层的深度有关，可在术前帮助临床医生决定手术范围。卵巢恶性肿瘤发病风险模型（ROMA）能成功预测盆腔包块患者中卵巢癌的高风险个体。在用血HE4鉴别诊断妇科疾病时应排除肺癌的干扰。

关键词: 卵巢肿瘤, ＣＡ－１２５抗原, 子宫内膜肿瘤, 子宫内膜异位症, 人附睾蛋白４

Abstract: Human epididymis protein 4 （HE4） was firstly found in epididymis epithelial cells，located in chromosome 20q12-13.1. It stretches approximately 12 kb. HE4 alone，or together with CA125 can not only help to identify benign or malignant ovarian tumors，and diagnose first stage ovarian cancer，but is also an important index to monitor post-operation effect and predict the possible recurrence after operation. HE4 in endometrial cancer patients of all stages would unexceptionally rises. HE4 diagnosing of early patients is more sensitive than CA125. HE4 is connected with the depth of the invasion of endometrial cancer. HE4 is a useful index for determining if lymph cleaning is necessary before operation. Risk of ovarian malignancy algorithm（ROMA） can successfully predict the high-risk patients with pelvic masses. In diagnosing gynecological diseases by HE4， the interference of lung cancer should be ruled out.

Key words: Ovarian neoplasms, ＣＡ－１２５ ａｎｔｉｇｅｎ, Ｅｎｄｏｍｅｔｒｉａｌ ｎｅｏｐｌａｓｍｓ, Ｅｎｄｏｍｅｔｒｉｏｓｉｓ, Ｈｕｍａｎ ｅｐｉｄｉｄｙｍｉｓ ｐｒｏｔｅｉｎ ４