国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (4): 324-326.

• 论著 • 上一篇    下一篇

高危型HPV感染及随访方式对CINⅠ转归的影响

姜 华   

  1. 300270 天津市滨海新区大港社区医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-08-15 发布日期:2013-08-15

The Impact of High-risk HPV Infection and Follow-up on the Prognosis of CIN Ⅰ

JIANG Hua   

  1. Department of Obstetrics and Gynecology， Dagang Community Hospital of Tianjin Binhai New Area， Tianjin 300270， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-08-15 Online:2013-08-15

PDF (PC)

5108

摘要： 目的：探讨高危型人乳头瘤病毒（HR-HPV）感染对轻度宫颈上皮内瘤变（CINⅠ）转归的影响，寻求CINⅠ合理的临床治疗方法。方法：选取2010年1月—12月在天津市滨海新区大港社区医院妇产科门诊经病理学诊断为CINⅠ的妇女，并按照HR-HPV检测结果和患者个人意愿，分为单纯随访组和物理治疗组，并定期随访薄层液基细胞学（TCT）和HR-HPV。结果：经过6，12，24个月随访发现，HR-HPV（-）组无疾病进展病例；HR-HPV（+）组累计进展4例，物理治疗组中进展1例。HR-HPV（-）组与HR-HPV（+）组比较，2组疾病转归差异有统计学意义（P＜0.01）；物理治疗组疾病进展率低于HR-HPV（+）组，差异有统计学意义（P＜0.01）；持续HR-HPV感染导致CINⅠ进展的可能性高。结论：持续性HR-HPV感染是CINⅠ进展的高危因素，应合理选择治疗方式，CINⅠ治疗应提倡规范化、个体化和人性化。

关键词: 宫颈上皮内瘤样病变, 乳头状瘤病毒科, 治疗

Abstract: Objective： To investigate the impact of high-risk human papillomavirus （HR-HPV） infection fate of mild cervical intraepithelial neoplasia（CIN Ⅰ）， and seek reasonable clinical treatment for CIN Ⅰ. Methods：Select the outpatient women who were diagnozed by pathology for CIN Ⅰ in the Dagang Community Hospital of Tianjin Binhai New Area from January to December in 2010， and divided these women into simple follow-up group and the physical therapy group in accordance with HR-HPV test results and patient wishes of the individual， regular follow-up of TCT and HR-HPV. Results： After 6， 12， and 24-month follow-up， HR-HPV（-） group had no cases of disease progression； HR-HPV（+） group has four cases in cumulative progression； progress physical therapy group has one case of disease progression. Compared HR-HPV（-） group with the HR-HPV（+） group， the difference in disease prognosis between the two groups was statistically significant（P＜0.01）； compared HR-HPV（+） group with the physical therapy group， the rate of disease progression in physiotherapy group was less than HR-HPV（+） group， the difference was statistically significant（P<0.01）. The persistent HR-HPV infection led to the likelihood of progression of CIN Ⅰ. Conclusions： Persistent HR-HPV infection is the risk factors for CIN Ⅰ progression，which should chose a reasonable treatment，the treatment for CIN Ⅰ should be promoted standardizeuy， individualizelly，and humanistically.

Key words: Cervical intraepithelial neoplasia, Papillomaviridae, Therapy