国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (3): 252-255.

• 综述 • 上一篇    下一篇

微小RNA在宫颈癌中的研究进展

王红红，郝敏，赵卫红   

  1. 030001 太原，山西医科大学第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-06-15 发布日期:2014-06-15
  • 通讯作者: 郝敏

MicroRNA in Cervical Cancer

WANG Hong-hong，HAO Min，ZHAO Wei-hong   

  1. The Second Hospital of Shanxi Medical University，Taiyuan 030001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-06-15 Online:2014-06-15
  • Contact: HAO Min

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摘要： 微小RNA（microRNA，miRNA）是一类由18～25个核苷酸小分子组成的非编码单链小RNA。大量研究表明，miRNA在细胞增殖、凋亡和肿瘤形成等方面发挥重要作用，与多种肿瘤的发生、发展、侵袭、转移密切相关，近年有关miRNA与宫颈癌关系的研究日益增多。在宫颈癌中miRNA表达谱存在明显异常，提示其可能在宫颈癌的发生和发展中扮演重要角色，但关于miRNA在宫颈癌中表达异常的调控机制目前研究较少，仍有待进一步研究。现就宫颈癌中miRNA的异常表达及其可能的调控机制进行综述。

关键词: 微RNAs, 宫颈肿瘤, 乳头状瘤病毒科, 后成说, 遗传

Abstract: MicroRNA（miRNA） is a family of 18-25 nucleotide non-coding RNA. Accumulating evidence indicated that miRNA played an important role in regulating the cells，proliferation，apoptosis and tumorigenesis. miRNA may be closely associated with a variety of tumor occurrence，development，invasion and metastasis. Great concern has been raised regarding the correlation between cervical cancer and miRNA recently. The aberrant expressions of several miRNAs in cervical cancer were demonstrated to be involved in the occurrence and development of cervical cancer. However researches on the abnormal expression and regulation mechanism of the miRNA in cervical cancer were not much，still need further research. Here is to discuss the relationship between miRNA and cervical cancer and the possible regulation mechanism of the abnormal expression of miRNA.

Key words: MicroRNAs, Uterine cervical neoplasms, Papillomaviridae, Epigenesis, genetic