国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 115-118.

• 综述 • 上一篇    下一篇

PKR转导通路失活与宫颈癌

罗远材,糜若然   

  1. 300192 天津医科大学一中心临床学院妇产科(罗远材)；天津医科大学总医院妇产科(糜若然)
  • 收稿日期:2009-07-31 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15

The Relationship Between Inactivating PKR Signal Transduction Pathway by Cervical Oncogenic Viruses and Cervical Cancer

LUO Yuan-cai, MI Ruo-ran   

  1. Department of Gynecology and Obstetrics, TianJin First Central Hospital of Tianjin Medical University, Tianjin 300192, China （LUO Yuan-cai）; Tianjin Medical University General Hospital, Tianjin 300052, China （MI Ruo-ran）
  • Received:2009-07-31 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15

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摘要： 干扰素诱导的双链RNA（dsRNA）激活的蛋白激酶R（PKR）是一种全身广泛表达的丝氨酸-苏氨酸蛋白激酶，具有特异的分子构型，是机体抑制病毒的关键靶点和肿
瘤抑制剂，是宿主防御机制中发动细胞死亡来对抗病毒感染和肿瘤形成的关键点。但宫颈感染人乳头瘤病毒（HPV）、单纯疱疹病毒（HSV）、人巨细胞病毒（HCMV）等致瘤病毒后
常使PKR处于失活状态，导致病毒感染扩散，病毒癌基因有机会整合入宿主细胞基因组内，表达病毒癌蛋白，破坏细胞周期自我调控和凋亡机制，延缓细胞死亡，干扰某些关键基因
的表达，导致某个细胞克隆永生化，最终诱发癌变。

关键词: 人乳头瘤病毒, 单纯疱疹病毒, 人巨细胞病毒, 蛋白激酶R, 宫颈癌

Abstract: Interferon-inducible double-stranded RNA （dsRNA）-activated protein kinase R （PKR） is a ubiquitously expressed serine-threonine
kinase which has a special molecular conformation. It is a key cellular target for viral repression and against tumor; it is also a key point of host defense
to trigger cell death in response to virus infection and tumorigenesis. After some oncogenic viruses such as human papillomavirus （HPV）, herpes simplex
virus（HSV）, human cytomegalovirus （HCMV） infect cervix, PKR is usually unactivated which leads to viruses extend and viral oncogenes have an
opportunity to integrate into the host cellular genome to express oncoprotein, disturb the mechanism of cell cycle regulation and apopsis, retard cell to
death, interfere the expression of some key genes to result in long life of some cell clone to induce to malignant change ultimately.

Key words: Human papillomavirus, Herpes simplex virus, Human cytomegalovirus, Protein kinase R, Cervical cancer