国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (3): 160-164.

• 综述 • 上一篇    下一篇

人类白细胞抗原G与子痫前期的相关性

贾艳菊,陈叙   

  1. 300052 天津市中心妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-15 发布日期:2010-06-15

Human Leukocyte Antigen G Research Progress and the Correlation with Preeclampsia

JIA Yan-ju, CHEN Xu   

  1. Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin 300052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-06-15 Online:2010-06-15

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摘要： 人类白细胞抗原G（HLA-G）为非经典的HLA-Ⅰ类分子，特异性高表达于母胎界面的绒毛外滋养细胞，通过诱导免疫耐受对妊娠和胚胎起到保护作用。子痫前期是产科领域危害母婴健康的主要疾病之一，子痫前期患者血清及胎盘组织HLA-G表达下降，但具体作用机制仍不清楚。随着基础研究的深入，明确了HLA-G基因、蛋白质的结构及遗传方式，在基因多态性方面做了大量研究工作，力求从基因水平阐明其与子痫前期的关系。发现部分子痫前期患者可能存在HLA-G基因缺陷，且HLA-G多态性在子痫前期及正常妊娠者中分布也不同。

关键词: 人类白细胞抗原G, 子痫前期, 基因, 多态性

Abstract: The human leukocyte antigen G（HLA-G） is non-classical HLA-I class I molecules highly expressing in the the extravillous trophoblast cells of maternal-fetal interface, which has protective effects to pregnancy and embryo by inducing immune tolerance. Pre-eclampsia is one of the major diseases in obstetric field, the expression of HLA-G in patients with preeclampsia, but the mechanism of action still unclear. The progress of basic research, the HLA-G gene and protein structures were defined, a lot of work have been done to clarify the relationship between HLA-G polymorphisms and preeclampsia in the gene level. It is found that some patients with pre-eclampsia maybe have HLA-G gene defect, and the distribution of HLA-G polymorphism was also different.

Key words: Human leukocyte antigen G, Preeclampsia, Gene, Polymorphism