国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (3): 165-167.

• 综述 • 上一篇    下一篇

促红细胞生成素及受体在妊娠维持中的作用

季玉琴,张玉泉,李大金   

  1. 226001 南通大学附属医院妇产科[（季玉琴、张玉泉），复旦大学附属妇产科医院妇产科研究所（李大金）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-15 发布日期:2010-06-15

Roles of Erythropoietin and Receptor in Pregnancy Maintenance

JI Yu-qin, ZHANG Yu-quan, LI Da-jin   

  1. Department of Obstetrics and Gynecology, the Affiliated Hospital of Nantong University，Nantong, 226001, China（JI Yu-qin）（ZHANG Yu-quan）；Hospital and Institute of Obstetrics and Gyecology, Fudan University Shanghai Medical College, Shanghai 200011 China（LI Da-jin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-06-15 Online:2010-06-15

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摘要： 促红细胞生成素(EPO)是一类新发现的促血管生成因子，通过与其受体（EPOR）结合引发信号转导，具有促进血管生成、抗凋亡、抗缺氧作用，参与胎盘血管发生、肿瘤血管形成及转移等过程。EPO及EPOR在母-胎界面均有表达，对妊娠全过程起重要作用。妊娠过程中EPO/EPOR表达异常，可能与流产、子痫前期、胎儿生长受限等的发病有关。深入研究EPO在妊娠疾病中的作用，为妊娠疾病的诊断和治疗提供重要理论依据。

关键词: 促红细胞生成素, 血管生成, 妊娠

Abstract: The erythropoietin (EPO) is a novel family of angiogenic factors that promote angiogenesis, anti-apoptosis and anti-hypoxia when binding its receptor（EPOR）. The EPO participates in the development of placenta vessels, as well as the angiogenesis and tumor metastasis. EPO and its receptor expressed at reside maternal-fetal interface. Since EPO and its receptor are expressed throughout human gestation, it may play a pivotal role in pregnancy, and their abnormal regulation may be involved in spontaneous abortion, eclampsia and fetal growth restriction. Therefore, EPO in pregnancy may present a novel strategy for treatment of the pregnancy-related diseases.

Key words: Erythropoietin, Angiogenesis, Pregnancy