国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (1): 27-30.

• 综述 • 上一篇    下一篇

血小板膜糖蛋白Ⅱb/Ⅲa受体与子痫前期

程淑清;黄亚绢   

  1. 200233 上海市第六人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-15 发布日期:2010-02-15
  • 通讯作者: 黄亚绢

Relationship Between Platelet Membrane Glycoprotein Ⅱb/Ⅲa Receptor and Preeclampsia

CHENG Shu-qing;HUANG Ya-juan   

  1. Department of Obstetrics and Gynecology, the Sixth People Hospital of Shanghai, Shanghai 200233, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-02-15 Online:2010-02-15
  • Contact: HUANG Ya-juan

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摘要： 糖蛋白Ⅱb/Ⅲa（glycoproteinⅡb/Ⅲa，GPⅡb/Ⅲa）受体是血小板膜上最丰富的一种蛋白，在血小板聚集、血栓形成过程中起关键性调节作用。子痫前期是一种病因不明伴有多系统功能障碍的病理妊娠，表现为高血压、蛋白尿、高凝血、高纤溶倾向，是围产期孕产妇死亡的主要原因，又是产妇远期并发心脑血管疾病的高危因素。GPⅡb/Ⅲa受体在子痫前期发病过程中起“承前启后”的调节作用，有可能为子痫前期的病因探索、临床治疗提供新的突破。

关键词: 糖蛋白Ⅱb/Ⅲa, 整合素αⅡbβ3, 子痫前期, 血栓形成

Abstract: GPⅡb/Ⅲa receptor is the most redundant glycoprotein on platelet membrane, and palys a critical role in the process of platelet aggregation and thrombosis. Preeclampsia is a pathogestation with polysystem imbalance, characterized with hypertension, proteinuria, hypercoagulation, hyperfibrinolysis tendency, and is associated with high maternal high morbidity and mortality and parturient cardiovascular and cerebrovascular disorders in long term. GPⅡb/Ⅲa receptor is a key component in the process of preeclampsia invasion, which could provide original breakthrough for its etiopathogenisis and clinical therapy.

Key words: Glycoprotein Ⅱb/Ⅲa, Integrin αⅡbβ3, Preeclampsia, Thrombosis