国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (3): 190-193.

• 综述 • 上一篇    下一篇

微小RNA 在宫颈癌中的研究进展

高翔,张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-15 发布日期:2010-06-15

Advance Research About miRNA in Cervical Cancer

GAO Xiang, ZHANG Shu-lan   

  1. Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-06-15 Online:2010-06-15

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摘要： 微小RNA（microRNA，miRNA）是一类小分子的非编码调控的单链RNA。研究发现，miRNA参与有机体的一系列生理过程，包括基因表达调控和细胞增殖、分化、凋亡等，与人类的多种疾病密切相关。目前，miRNA在宫颈癌的研究尚处于初级阶段，主要包括miRNA在宫颈癌的表达检测；miRNA与宫颈癌的发生、分化、转移、预后的相关性及其机制的研究；及miRNA在宫颈癌的诊断、治疗等应用方面的探索。

关键词: 微小RNA, 宫颈癌, 基因沉默, 作用机制

Abstract: microRNA is a class of small, endogenous, noncoding single-stranded RNA molecules. Past studies have indicated that miRNAs play important roles in diverse biological processes including gene expression regulation, cell proliferation, differentiation and apoptosis；Their expression have been correlated with various diseases. At present，the research on miRNA in cervical cancer is still in the primary stage，including the expression detection of cervical cancer, and cervial cancer development，differentiation, transfer diagnosis,therapy and prognosis.

Key words: MicroRNA, Cervical cancer, Gene silencing, Mechanism