国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 545-548.

• 综述 • 上一篇    下一篇

子痫前期相关微小RNA的研究进展

龙安雄,厉 倩   

  1. 200940 上海市第一人民医院宝山分院检验科(龙安雄,厉 倩);南昌大学医学院(龙安雄)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 厉 倩

Recent Advances in Preeclampsia-related MicroRNAs

LONG An-xiong，LI Qian   

  1. Department of Clinical Laboratory，Shanghai First People′s Hospital Baoshan Branch，Shanghai 200940，China（LONG An-xiong，LI Qian）；Medical School of Nanchang University，Nanchang 330006，China（LONG An-xiong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15
  • Contact: LI Qian

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摘要： 子痫前期（preeclampsia，PE）是妊娠20周后出现的特发性高血压综合征，其病因和发病机制至今仍未完全阐明。微小RNA（microRNA，miRNA）是一类内源性的单链非编码 RNA。新近研究证实，PE胎盘中存在异常表达的miRNA，分析母体血清miRNA表达谱有助于PE的早期预测，进一步研究PE相关miRNA及其靶基因的功能可能有助于阐明PE的发病机制，进而为PE的预防和治疗提供新思路。综述新近发现的与PE密切相关的miRNA的研究进展。

关键词: 先兆子痫, 微RNAs, 胎盘, 基因, 血清学

Abstract: Preeclampsia（PE） is an idiopathic hypertension syndrome that occur after 20th week of gestation，whose etiology and pathogenesis have not yet been completely elucidated. MicroRNA（miRNA） is a class of endogenous single-stranded small non-coding RNA. Recent studies verified abnormal expression of miRNAs in placenta of preeclampsia and screening of maternal serum miRNAs expression spectrum helped early prediction of PE. Further investigation of PE-related miRNAs and their target genes would contribute to demonstration of PE pathogenesis，then provide new ways for the prevention and treatment of PE. This review summarized recent advances in PE-related miRNAs.

Key words: Pre-eclampsia, MicroRNAs, Placenta, Genes, Serology