Abstract:

Existing studies suggest that it takes decades for cervical precancerous lesions to progress to cervical cancer. Therefore, cervical cancer is a preventable gynecological malignant tumor, and the key to its prevention is to screen out cervical lesions as soon as possible. Based on China′s national conditions, the majority of cervical lesions screening still choose a single thin-prep cytology test(TCT) examination or HPV DNA detection to shunt TCT results abnormal way, resulting in missed diagnosis or over diagnosis of cervical lesions in clinical work. To choose the best screening method to improve the diagnosis rate of cervical lesions is an urgent problem in the prevention and control of cervical cancer. Epigenetic accumulation of genes regulated by DNA methylation may mediate or predict the progression of malignant tumors. The key mechanism of carcinogenesis lies in the suppression of gene expression through promoter silencing, leading to global hypomethylation and gene specific hypermethylation. It has been confirmed that there is an increase in the methylation level of specific genes in cervical lesions. Because of its high specificity, it is also developed as a new additional tool for cervical lesions screening. This article will make a brief review of the related gene methylation in predicting cervical lesions.

Key words: Uterine cervical neoplasms, DNA methylation, Precancerous conditions, Mass screening, Diagnosis