The Role of S100 Protein in Endometriosis

doi:10.12280/gjfckx.20220524

Abstract

Abstract:

The S100 protein family is a family of 25 members of calcium-binding proteins that bind to Ca²⁺ and perform biological functions inside and outside the cell, regulating various cellular processes such as proliferation, differentiation, inflammation, migration and invasion, apoptosis, Ca²⁺ homeostasis and energy metabolism. They are closely associated with the development of many cancers, inflammatory diseases and immune disorders. Endometriosis (EMs) has a complex pathogenesis and is a chronic inflammatory disease that can cause pelvic pain and infertility. There are no accurate and easily accessible early non-invasive diagnostic methods and clear therapeutic targets. Studies have shown that S100B, S100A7 and S100A8 can participate in the inflammatory response by activating the nuclear factor-κB (NF-κB) signaling pathway; S10013 can participate in neovascularization and promotes disease progression by synergizing with other pro-angiogenic factors; S100A4, S100A6 and S100P may induce cell migration and invasion through Wnt/β-catenin signaling pathway and/or p38 MAPK signaling pathway. The research progress on the role of S100 protein family in the pathogenesis and diagnosis of EMs is reviewed to provide ideas for further applications of S100 proteins in EMs, and to provide references for the search of potential early diagnostic markers and therapeutic targets.

Key words: S100 proteins, Endometriosis, Inflammation, Neovascularization, pathologic, Diagnosis, Therapy

DUAN Yu-han, LI Nan, CHEN Lei, ZHANG Kun. The Role of S100 Protein in Endometriosis[J]. Journal of International Obstetrics and Gynecology, 2022, 49(5): 486-491.

References 36

[1]	Vetvicka V, Fiala L, Garzon S, et al. Endometriosis and gynaecological cancers: molecular insights behind a complex machinery[J]. Prz Menopauzalny, 2021, 20(4):201-206. doi: 10.5114/pm.2021.111276. doi: 10.5114/pm.2021.111276 pmid: 35069072
[2]	Surrey ES, Soliman AM, Yang H, et al. Treatment Patterns, Complications, and Health Care Utilization Among Endometriosis Patients Undergoing a Laparoscopy or a Hysterectomy: A Retrospective Claims Analysis[J]. Adv Ther, 2017, 34(11):2436-2451. doi: 10.1007/s12325-017-0619-3. doi: 10.1007/s12325-017-0619-3 pmid: 29039055
[3]	Moore BW. A soluble protein characteristic of the nervous system[J]. Biochem Biophys Res Commun, 1965, 19(6):739-744. doi: 10.1016/0006-291x(65)90320-7. doi: 10.1016/0006-291x(65)90320-7
[4]	Gonzalez LL, Garrie K, Turner MD. Role of S100 proteins in health and disease[J]. Biochim Biophys Acta Mol Cell Res, 2020, 1867(6): 118677. doi: 10.1016/j.bbamcr.2020.118677. doi: 10.1016/j.bbamcr.2020.118677
[5]	Bresnick AR, Weber DJ, Zimmer DB. S100 proteins in cancer[J]. Nat Rev Cancer, 2015, 15(2):96-109. doi: 10.1038/nrc3893. doi: 10.1038/nrc3893 pmid: 25614008
[6]	Wu YY, Li XF, Wu S, et al. Role of the S100 protein family in rheumatoid arthritis[J]. Arthritis Res Ther, 2022, 24(1):35. doi: 10.1186/s13075-022-02727-8. doi: 10.1186/s13075-022-02727-8
[7]	Wang S, Song R, Wang Z, et al. S100A8/A9 in Inflammation[J]. Front Immunol, 2018, 9:1298. doi: 10.3389/fimmu.2018.01298. doi: 10.3389/fimmu.2018.01298 pmid: 29942307
[8]	Xia C, Braunstein Z, Toomey AC, et al. S100 Proteins As an Important Regulator of Macrophage Inflammation[J]. Front Immunol, 2017, 8:1908. doi: 10.3389/fimmu.2017.01908. doi: 10.3389/fimmu.2017.01908 pmid: 29379499
[9]	Mahaling B, Low S, Beck M, et al. Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders[J]. Int J Mol Sci, 2022, 23(5):2591. doi: 10.3390/ijms23052591. doi: 10.3390/ijms23052591
[10]	Foell D, Wittkowski H, Vogl T, et al. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules[J]. J Leukoc Biol, 2007, 81(1):28-37. doi: 10.1189/jlb.0306170. doi: 10.1189/jlb.0306170
[11]	戴毅, 郎景和, 朱兰, 等. 子宫内膜异位症诊治的现在和未来[J]. 中国科学:生命科学, 2021, 51(8):1017-1023. doi: 10.1360/SSV-2021-0195. doi: 10.1360/SSV-2021-0195
[12]	Zondervan KT, Becker CM, Missmer SA. Endometriosis[J]. N Engl J Med, 2020, 382(13):1244-1256. doi: 10.1056/NEJMra1810764. doi: 10.1056/NEJMra1810764
[13]	Stefani LC, Leite FM, da Graça L Tarragó M, et al. BDNF and serum S100B levels according the spectrum of structural pathology in chronic pain patients[J]. Neurosci Lett, 2019, 706:105-109. doi: 10.1016/j.neulet.2019.05.021. doi: S0304-3940(19)30339-8 pmid: 31100426
[14]	Villarreal A, Seoane R, González Torres A, et al. S100B protein activates a RAGE-dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis[J]. J Neurochem, 2014, 131(2):190-205. doi: 10.1111/jnc.12790. doi: 10.1111/jnc.12790 pmid: 24923428
[15]	Sun Q, Cao Y, Lan Y, et al. S100A7 promotes the development of human endometriosis by activating NF-κB signaling pathway in endometrial stromal cells[J]. Cell Biol Int, 2021, 45(6):1327-1335. doi: 10.1002/cbin.11578. doi: 10.1002/cbin.11578 pmid: 33675277
[16]	Zheng J, Wang J, Liu H, et al. Alarmins S100A8/A9 promote intervertebral disc degeneration and inflammation-related pain in a rat model through toll-like receptor-4 and activation of the NF-κB signaling pathway[J]. Osteoarthritis Cartilage, 2022, 30(7):998-1011. doi: 10.1016/j.joca.2022.03.011. doi: 10.1016/j.joca.2022.03.011
[17]	Su W, Cui H, Wu D, et al. Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis[J]. J Neuroinflammation, 2021, 18(1):65. doi: 10.1186/s12974-020-02066-y. doi: 10.1186/s12974-020-02066-y
[18]	Ferrero S, Gillott DJ, Remorgida V, et al. Proteomic analysis of peritoneal fluid in women with endometriosis[J]. J Proteome Res, 2007, 6(9):3402-3411. doi: 10.1021/pr060680q. doi: 10.1021/pr060680q pmid: 17676783
[19]	Geven EJ, van den Bosch MH, Di Ceglie I, et al. S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis[J]. Arthritis Res Ther, 2016, 18(1):247. doi: 10.1186/s13075-016-1121-z. doi: 10.1186/s13075-016-1121-z pmid: 27776554
[20]	Shi S, Yi JL. S100A8/A9 promotes MMP-9 expression in the fibroblasts from cardiac rupture after myocardial infarction by inducing macrophages secreting TNFα[J]. Eur Rev Med Pharmacol Sci, 2018, 22(12):3925-3935. doi: 10.26355/eurrev_201806_15278. doi: 10.26355/eurrev_201806_15278
[21]	梁月明, 张培芳, 魏晓群, 等. 慢性阻塞性肺疾病患者血清S100A8/A9、CX3CL1联合检测的临床价值[J]. 国际检验医学杂志, 2021, 42(22):2740-2744. doi: 10.3969/j.issn.1673-4130.2021.22.011. doi: 10.3969/j.issn.1673-4130.2021.22.011
[22]	Saunders P, Horne AW. Endometriosis: Etiology, pathobiology, and therapeutic prospects[J]. Cell, 2021, 184(11):2807-2824. doi: 10.1016/j.cell.2021.04.041. doi: 10.1016/j.cell.2021.04.041 pmid: 34048704
[23]	Laschke MW, Menger MD. Basic mechanisms of vascularization in endometriosis and their clinical implications[J]. Hum Reprod Update, 2018, 24(2):207-224. doi: 10.1093/humupd/dmy001. doi: 10.1093/humupd/dmy001 pmid: 29377994
[24]	Jadhao M, Chen CL, Liu W, et al. Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells[J]. Biomedicines, 2022, 10(2):417. doi: 10.3390/biomedicines10020417. doi: 10.3390/biomedicines10020417
[25]	Arimoto T, Katagiri T, Oda K, et al. Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis[J]. Int J Oncol, 2003, 22(3):551-560. pmid: 12579308
[26]	Hayrabedyan S, Kyurkchiev S, Kehayov I. FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis[J]. J Reprod Immunol, 2005, 67(1/2):87-101. doi: 10.1016/j.jri.2005.07.001. doi: 10.1016/j.jri.2005.07.001
[27]	Cao R, Yan B, Yang H, et al. Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells[J]. J Formos Med Assoc, 2010, 109(9):632-640. doi: 10.1016/S0929-6646(10)60103-9. doi: 10.1016/S0929-6646(10)60103-9
[28]	Hua T, Wang X, Chi S, et al. Estrogen-related receptor γ promotes the migration and metastasis of endometrial cancer cells by targeting S100A4[J]. Oncol Rep, 2018, 40(2):823-832. doi: 10.3892/or.2018.6471. doi: 10.3892/or.2018.6471
[29]	唐莉, 李东娅, 章晓梅. S100A4在子宫内膜内异症患者在位、异位子宫内膜及正常人子宫内膜组织中的表达[J]. 中国现代医学杂志, 2009, 19(20):3084-3086,3090. doi: 10.3969/j.issn.1005-8982.2009.20.011, doi: 10.3969/j.issn.1005-8982.2009.20.011
[30]	Wang X, Tian T, Li X, et al. High expression of S100P is associated with unfavorable prognosis and tumor progression in patients with epithelial ovarian cancer[J]. Am J Cancer Res, 2015, 5(8):2409-2421. pmid: 26396916
[31]	Cross SS, Hamdy FC, Deloulme JC, et al. Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers[J]. Histopathology, 2005, 46(3):256-269. doi: 10.1111/j.1365-2559.2005.02097.x. doi: 10.1111/j.1365-2559.2005.02097.x pmid: 15720411
[32]	Peng Y, Lin J, Ma J, et al. Upregulation of S100A6 in patients with endometriosis and its role in ectopic endometrial stromal cells[J]. Gynecol Endocrinol, 2018, 34(9):815-820. doi: 10.1080/09513590.2018.1451506. doi: 10.1080/09513590.2018.1451506 pmid: 29544367
[33]	Liu Z, Zhang X, Chen M, et al. Effect of S100A6 over-expression on β-catenin in endometriosis[J]. J Obstet Gynaecol Res, 2015, 41(9):1457-1462. doi: 10.1111/jog.12729. doi: 10.1111/jog.12729
[34]	Shi L, Xue X, Tian H, et al. WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway[J]. Reprod Biol Endocrinol, 2021, 19(1):161. doi: 10.1186/s12958-021-00844-8. doi: 10.1186/s12958-021-00844-8
[35]	王岩, 马宁耶, 汤丽红, 等. KLF4与S100A14在子宫内膜异位症相关性卵巢癌中的表达及临床意义[J]. 现代肿瘤医学, 2019, 27(14):2565-2570. doi: 10.3969/j.issn.1672-4992.2019.14.033. doi: 10.3969/j.issn.1672-4992.2019.14.033
[36]	Hsiao IH, Lin YW. Electroacupuncture Reduces Fibromyalgia Pain by Attenuating the HMGB1, S100B, and TRPV1 Signalling Pathways in the Mouse Brain[J]. Evid Based Complement Alternat Med, 2022, 2022:2242074. doi: 10.1155/2022/2242074. doi: 10.1155/2022/2242074