Abstract:

Adenosquamous carcinoma is a malignant neoplasm exhibiting both adenocarcinoma and squamous cell carcinoma components. Primary ovarian adenosquamous carcinoma is exceedingly rare, with poorly understood pathogenesis and clinicopathological features, and carries a poor prognosis. This report presents a case of stage ⅣB primary ovarian adenosquamous carcinoma. The 53-year-old female patient presented with lower abdominal distension and was found to have a heterogeneous echoic mass in the right adnexal. Following optimal cytoreduction surgery and six cycles of intravenous chemotherapy, platinum- resistant recurrence occurred. Subsequently, she underwent radiotherapy to the para-aortic lymph node recurrence site. However, three months later, tumor recurrence at the intestinal anastomosis site led to bowl obstruction, necessitating further surgery. While surgical resection is the primary treatment for primary ovarian adenosquamous carcinoma, lymphadenectomy or sampling is recommended in advanced stages. Platinum-based chemotherapy is the standard post-operative regimen. Future treatment directions may involve genomic profiling and immunotherapy. For recurrence disease，individualized treatment strategies should be tailored to the metastatic site and characteristics.

Key words: Adenosquamous carcinoma, Ovarian neoplasms, Recurrence, Pathogenesis, Therapy, Drug resistance, neoplasm